Subcellular localization of angiotensin II in kidney and adrenal

Journal of Hypertension
J P van KatsA H Danser

Abstract

To investigate whether tissue angiotensin II generation occurs intra- or extracellularly, we studied the subcellular localization of angiotensin II in kidney and adrenal, two organs with high endogenous angiotensin II concentrations. Tissues were obtained, following a 1 h infusion of 125I-angiotensin I or 125I-angiotensin II to simultaneously determine the localization of plasma-derived angiotensin II, from five control pigs and four pigs that had been pretreated with the AT1 receptor antagonist eprosartan. Subcellular organelles, prepared by differential centrifugation from homogenized tissue, were characterized using organelle-specific markers. 125I-angiotensin II and angiotensin II were present in all organelles, with identical distribution profiles. In mitochondria-enriched fractions the relative specific activities [RSAs = (concentration per mg protein in fraction)/(concentration per mg protein in homogenate)] of the two peptides were similar to those in homogenate, whereas in cytosol-enriched fractions their RSAs were five- to 10-fold lower (P< 0.05 versus homogenate). In microsome- as well as in lysosome-enriched fractions the RSAs of 125I-angiotensin II and angiotensin II were two- to four-fold higher than in homogenate...Continue Reading

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Citations

Mar 8, 2005·Current Hypertension Reports·Wenxia Chai, A H Jan Danser
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·A H Jan Danser
Jan 12, 2002·British Journal of Pharmacology·Martin P SchuijtA H Jan Danser
Dec 12, 2001·Kidney International·J P van KatsA H Danser
Nov 13, 2001·Current Opinion in Cardiology·R N Re
Aug 18, 2004·Journal of Hypertension·A H Jan Danser
Dec 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brianne EllisJia L Zhuo
Dec 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julia L Cook, Richard N Re
May 10, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jia L Zhuo, Xiao C Li
Aug 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xifeng LuAlexander H Jan Danser
Jan 9, 2013·Current Hypertension Reports·Lodi C W RoksnoerA H Jan Danser
Nov 15, 2002·Journal of Molecular and Cellular Cardiology·A H Jan Danser, Jasper J Saris
Feb 22, 2012·Expert Opinion on Investigational Drugs·Koen VerdonkJoep H M van Esch
Mar 31, 2006·Kidney International·M A D H Schalekamp, A H J Danser
Apr 22, 2015·American Journal of Hypertension·A H Jan Danser
Apr 21, 2011·Pharmacology & Therapeutics·Els MoltzerA H Jan Danser
Dec 3, 2016·American Journal of Physiology. Renal Physiology·Bryan A WilsonMark C Chappell
Aug 25, 2010·Hypertension·Mieke van den HeuvelA H Jan Danser
Apr 12, 2017·Hypertension·Bibi S van ThielA H Jan Danser
Jan 2, 2015·Circulation Research·Carlos M Ferrario, Ernesto L Schiffrin
Apr 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Wendy W BatenburgA H Jan Danser
Mar 8, 2002·Hypertension·Jasper J SarisA H Jan Danser
Aug 18, 2005·American Journal of Physiology. Renal Physiology·Maria Claudina Camargo de AndradeDulce Elena Casarini
Dec 14, 2007·American Journal of Physiology. Renal Physiology·Rudy M Ortiz
Dec 8, 2007·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Veena RaizadaJeffrey Griffith
Apr 3, 2019·Journal of Cardiovascular Development and Disease·Ali NehmeKazem Zibara
Apr 13, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Nelson EscobalesSabzali Javadov
Dec 25, 2015·American Journal of Physiology. Renal Physiology·Bryan A WilsonMark C Chappell
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Irene KoukoulasE Marelyn Wintour
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Dominique M BoveeEwout J Hoorn
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·A H Jan Danser
Mar 17, 2020·Current Hypertension Reports·Yuan SunA H Jan Danser
May 2, 2018·Clinical Science·Estrellita UijlA H Jan Danser
Apr 6, 2019·Current Hypertension Reports·Liwei RenA H Jan Danser

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