Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in adrenocortical carcinoma.

BMC Research Notes
Matthias HaaseMargret Ehlers

Abstract

Fibroblast growth factor receptor (FGFR) 2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells. The activation of the Wingless/Int-1 (WNT)/beta catenin pathway as a key mechanism of adrenocortical tumourigenesis has been linked to FGFR2 signalling in other cell types. Therefore we hypothesised that FGFR2 expression may also play a role in adrenocortical carcinoma (ACC). We conducted a pilot study and analysed protein expression of FGFR2 in 26 ACCs using immunohistochemistry technique. Data on the CTNNB1 mutation status and clinical data were correlated to the expression of FGFR2. We observed a high variability in FGFR2 expression between the different tumour samples. There was a subset of ACC with comparatively high nuclear expression of FGFR2. We did not find a clear association between the CTNNB1 mutational status or clinical features and the FGFR2 expression. We conclude that FGFR signalling plays a role in adrenocortical carcinoma. Our data encourages further investigations of FGFR signalling in ACC, especially since new inhibitors of FGFR signalling are already entering clinical tria...Continue Reading

References

Aug 26, 1998·The Journal of Endocrinology·J J FeigeS Souchelnitskiy
Feb 7, 2007·The Journal of Endocrinology·Matthias HaaseHolger S Willenberg
Feb 5, 2013·Molecular and Cellular Endocrinology·Leonardo GuastiPeter J King
Nov 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero
Dec 10, 2014·The Journal of Clinical Endocrinology and Metabolism·C Christofer JuhlinTobias Carling
Jul 5, 2015·Molecular and Cellular Endocrinology·Regine HäfnerAndreas Kispert
Jul 21, 2015·Frontiers in Cell and Developmental Biology·Rossella Libé
Mar 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Tabernero

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Methods Mentioned

BETA
PCR
Assay
exome sequencing
PCRs

Software Mentioned

Prism
GraphPad

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