PMID: 6111299Dec 1, 1980Paper

Subcellular localization of long-chain alcohol dehydrogenase and aldehyde dehydrogenase in n-alkane-grown Candida tropicalis

Archives of Microbiology
T YamadaS Fukui

Abstract

Long-chain alcohol dehydrogenase and long-chain aldehyde dehydrogenase were induced in the cells of Candida tropicalis grown on n-alkanes. Subcellular localization of these dehydrogenases, together with that of acyl-CoA synthetase and glycerol-3-phosphate acyltransferase, was studied in terms of the metabolism of fatty acids derived from n-alkane substrates. Both long-chain alcohol and aldehyde dehydrogenases distributed in the fractions of microsomes, mitochondria and peroxisomes obtained from the alkane-grown cells of C. tropicalis. Acyl-CoA synthetase was also located in these three fractions. Glycerol-3-phosphate acyltransferase was found in microsomes and mitochondria, in contrast to fatty acid beta-oxidation system localized exclusively in peroxisomes. Similar results of the enzyme localization were also obtained with C. lipolytica grown on n-alkanes. These results suggest strongly that microsomal and mitochondrial dehydrogenases provide long-chain fatty acids to be utilized for lipid synthesis, whereas those in peroxisomes supply fatty acids to be degraded via beta-oxidation to yield energy and cell constituents.

References

Oct 1, 1977·Applied and Environmental Microbiology·A TanakaS Fukui
Feb 1, 1978·European Journal of Biochemistry·S KawamotoS Fukui
Jan 16, 1978·European Journal of Biochemistry·M MishinaS Numa
Sep 1, 1978·European Journal of Biochemistry·M MishinaS Numa
Feb 6, 1976·Biochimica Et Biophysica Acta·M GalloE Azoulay
Feb 4, 1977·Archives of Microbiology·S KawamotoS Fukui
Apr 1, 1977·Applied and Environmental Microbiology·V R ParekhJ M Sobek
Jun 20, 1977·Biochemical and Biophysical Research Communications·C L Jones, A K Hajra
Aug 1, 1973·Journal of Bacteriology·J D Walker, J J Cooney
Oct 1, 1973·Canadian Journal of Microbiology·J D Walker, J J Cooney
Dec 16, 1970·Biochimica Et Biophysica Acta·J M LebeaultE Azoulay

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Citations

Dec 15, 1982·European Journal of Biochemistry·T YamadaS Fukui
Aug 1, 1992·Antonie van Leeuwenhoek·W H Kunau, A Hartig
Jan 1, 1982·Annals of the New York Academy of Sciences·A TanakaS Fukui
Oct 16, 2014·The Journal of Biological Chemistry·Ryo IwamaRyouichi Fukuda
Jun 21, 2021·Biotechnology Advances·David RibeaucourtJean-Guy Berrin

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