PMID: 8954756Dec 1, 1996Paper

Subcellular localization of TCDD differs between the liver, lungs, and kidneys after acute and subchronic exposure: species/dose comparisons and possible mechanism

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
M J SantostefanoL S Birnbaum

Abstract

Subcellular localization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds has been examined only in the liver. The objective of this study was (1) to examine and compare the subcellular distribution of TCDD within hepatic and nonhepatic (lungs/kidneys) tissues of female Sprague-Dawley rats acutely exposed to TCDD, (2) to analyze species comparisons in the subcellular localization of TCDD in multiple tissues, (3) to investigate the effect of dose on subcellular distribution of TCDD, (4) to analyze the effect of subchronic exposure on the subcellular distribution of TCDD, and (5) to examine one possible mechanism for subcellular localization of TCDD. Female Sprague-Dawley rats and B6C3F1 mice received a single oral dose of 0.1, 1.0, or 10 microg [3H]TCDD/kg body weight and subcellular fractions of the liver, lungs, and kidneys were prepared by differential centrifugation 3 days after exposure. Analysis of the rat subcellular fractions revealed that TCDD was equally distributed between the hepatic P9 (mitochondrial, lysosomal, and nuclear) and S9 (cytosol and microsomal) fractions at all doses tested. In contrast, TCDD was concentrated in the P9 of rat nonhepatic tissues at all doses studied. Differential centri...Continue Reading

Citations

Sep 18, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Paul C BoutrosPatricia A Harper
Dec 7, 2007·Ecotoxicology and Environmental Safety·A L BlankenshipJ P Giesy
Sep 16, 1999·Journal of Biochemical and Molecular Toxicology·K Hu, N J Bunce
Mar 2, 2006·European Journal of Clinical Investigation·C BethuneA-K Lundebye
Nov 5, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Lesa L AylwardColleen Beall
Nov 20, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom
Jul 18, 1997·Biochemical and Biophysical Research Communications·J J DilibertoL S Birnbaum

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