PMID: 668699Jun 15, 1978Paper

Subcellular metabolite concentrations. Dependence of mitochondrial and cytosolic ATP systems on the metabolic state of perfused rat liver

European Journal of Biochemistry
S SobollH W Heldt


Mitochondrial and cytosolic contents of adenine nucleotides and phosphate were measured in perfused rat livers employing a technique of fractionation of freeze-fixated tissue in non-aqueous solvents. From the subcellular contents the mitochondrial and cytosolic concentrations of ATP, ADP, AMP and phosphate and the phosphorylation potentials of the subcellular ATP systems were calculated. An attempt was made to elucidate the relationship between mitochondrial and cytosolic adenine nucleotide systems and the dependency on the metabolic state of the liver. The following results were obtained: 1. Under all metabolic conditions studied the mitochondrial ATP/ADP ratios were considerably lower than the cytosolic ratios (mitochondria: 0.1-0.7; cytosol: 2-11). 2. The ATP/ADP ratios calculated from overall tissue contents reflect mainly the cytosolic ratios. 3. An inverse relationship was found between mitochondrial and cytosolic ATP/ADP ratios, i.e. when the mitochondrial ratios tended to increase, the cytosolic ratios decreased and vice versa. 4. The phosphorylation potentials calculated from the subcellular concentrations were higher in the cytosol than in the mitochondria. The potential difference varied between 11 and 3 kj/mol in li...Continue Reading


Feb 15, 1977·European Journal of Biochemistry·Martin Klingenberg, H Rottenberg
May 1, 1977·Archives of Biochemistry and Biophysics·M E TischlerJ R Williamson
Apr 1, 1976·European Journal of Biochemistry·R Scholz, H Nohl
Oct 1, 1969·European Journal of Biochemistry·R G Thurman, R Scholz
Jan 1, 1971·Metabolism: Clinical and Experimental·J R WilliamsonR Scholz
Nov 7, 1972·European Journal of Biochemistry·H W HeldtM Milovancev
Oct 17, 1968·European Journal of Biochemistry·E Pfaff, Martin Klingenberg


Nov 9, 1994·Molecular and Cellular Biochemistry·T W Traut
Jan 1, 1982·The Journal of Membrane Biology·M Erecińska, D F Wilson
Dec 1, 1995·Journal of Bioenergetics and Biomembranes·S Soboll
Jan 1, 1981·The International Journal of Biochemistry·J H OttawayC L Saunderson
Jan 1, 1982·The International Journal of Biochemistry·R Rognstad
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry· Kaminsky YuG, E A Kosenko
Jan 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·W W Muhonen, D O Lambeth
Jan 1, 1979·Neuroscience·M Ng, A Matus
Nov 19, 2013·Fitoterapia·Rodrigo Polimeni ConstantinJorgete Constantin
Dec 3, 1999·European Journal of Biochemistry·E K Ainscow, M D Brand
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G ThomasJ Gordon
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E Furuya, K Uyeda
Jul 10, 2007·The Journal of Biological Chemistry·Philip P ChamberlainGlen Spraggon
Aug 1, 1980·European Journal of Biochemistry·J Stucki
Nov 2, 1984·European Journal of Biochemistry·T MatsumuraR G Thurman
May 1, 1987·Biological Reviews of the Cambridge Philosophical Society·M D Brand, M P Murphy
Jan 1, 1986·Annals of the New York Academy of Sciences·H P SchultheissMartin Klingenberg
May 15, 2009·Molecular Pharmacology·Stephen B Shears
Dec 1, 1985·Archives internationales de physiologie et de biochimie·P CanioniP J Cozzone
Nov 30, 2013·BioMed Research International·Rodrigo Polimeni ConstantinJorgete Constantin
Dec 1, 1982·Bioscience Reports·B D Uhal, K L Roehrig
Oct 21, 2014·PLoS Computational Biology·Markus RehbergUdo Reichl
Jan 1, 1985·CRC Critical Reviews in Biochemistry·J D Moyer, J F Henderson
May 31, 2008·Biochimica Et Biophysica Acta·Martin Klingenberg
Dec 17, 2014·Biotechnology and Bioengineering·Jinrui ZhangSebastian Aljoscha Wahl
May 29, 2014·Molecular & Cellular Proteomics : MCP·Stéphanie ArrivaultWaltraud X Schulze
Oct 21, 2016·Nature Communications·Jeanne M O Eloundou-MbebiZoran Nikoloski
Sep 30, 2006·Journal of Biochemical and Molecular Toxicology·Leandro Silva PivatoA Bracht
Nov 1, 2006·NMR in Biomedicine·Britton ChanceMartin Kushmerick
Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F DesmoulinP J Cozzone
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B E AkinsholaE Mezey
May 28, 2005·Cell Biochemistry and Function·Daniele GimenesA Bracht
Aug 4, 2010·Molecular and Cellular Biochemistry·Márcio Shigueaki MitoA Bracht
May 5, 2011·Journal of Neuroscience Research·Christos Chinopoulos
May 12, 1998·The American Journal of Physiology·G Magnus, J Keizer
May 31, 2017·Journal of Biochemical and Molecular Toxicology·Lorena Dos Santos CastroA Bracht
May 1, 1980·European Journal of Biochemistry·A JakobS Diem
Jun 13, 2008·Molecular and Cellular Biochemistry·Ana Carla Broetto-BiazonA Bracht
Apr 8, 2018·Toxicology Letters·Gilson Soares do NascimentoRodrigo Polimeni Constantin
May 27, 2020·Journal of Molecular and Cellular Cardiology·Michael J BroundJeffery D Molkentin
Feb 21, 2013·Chemico-biological Interactions·Caroline T MoreiraA Bracht
May 6, 1996·Chemico-biological Interactions·M O HüblerA Bracht
Feb 27, 1984·Biochimica Et Biophysica Acta·S HebischH Sies
Mar 30, 1984·Biochimica Et Biophysica Acta·G A KlugD Brdiczka
Dec 23, 1981·Biochimica Et Biophysica Acta·M J MüllerH J Seitz
Nov 12, 1990·Biochimica Et Biophysica Acta·A M BodeG A Klug
Jul 25, 1990·Biochimica Et Biophysica Acta·D BrdiczkaV K Nalam
Apr 20, 1983·Biochimica Et Biophysica Acta·M J Müller, H J Seitz
May 31, 1985·Biochimica Et Biophysica Acta·S Soboll, J Stucki
Aug 12, 1987·Biochimica Et Biophysica Acta·W HalangkW Kunz
Sep 25, 1992·Biochimica Et Biophysica Acta·M WyssT Wallimann
Oct 26, 1988·Biochimica Et Biophysica Acta·R J WiesnerM K Grieshaber

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.