Subchondral bone and cartilage repair with bioactive glasses, hydroxyapatite, and hydroxyapatite-glass composite

Journal of Biomedical Materials Research
E SuominenA Yli-Urpo

Abstract

The repair of an osteochondral defect in rabbit femur was studied with three kinds of bioactive glasses (BG), hydroxyapatite (HA), and hydroxyapatite-glass (HAG) composite. Seventy-two osteochondral defects were created in 18 rabbits. Sixty-four cylinders were implanted and eight defects were left empty as controls. Histomorphometry, scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDXA) were used for evaluation. Small osteochondral defects in rabbit femur found to heal themselves by regeneration. The three BGs, HA, and HAG led to direct lamellar bone repair of subchondral bone and restoration of articular surfaces mostly with hyalinelike cartilage in 12 weeks. However, the composition of the materials affects their behavior. Chondrogenesis took place earlier with the BGs than with HA. HAG degraded too much, glass 14 was too reactive and brittle, and the high alumina content in glass 11 disturbed its bone-bonding ability. Glass 7 and HA were the most balanced in the repair process. A special preparation method was used to retain soft tissues fairly unchanged and enable them to the observed together with hard tissues in SEM analysis.

References

Mar 1, 1977·Journal of Biomedical Materials Research·R T ChiroffD Roy
Mar 1, 1991·Journal of Biomedical Materials Research·H P von SchroederR D Coutts
Jan 1, 1987·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·H J Jaroma, V A Ritsilä
Mar 1, 1985·Journal of Biomedical Materials Research·U Gross, V Strunz
Jan 1, 1973·Journal of Biomedical Materials Research·L L Hench, H A Paschall
Nov 1, 1981·Journal of Biomedical Materials Research·J WilsonL L Hench
Jan 1, 1995·International Orthopaedics·E A SuominenA Yli-Urpo
Sep 1, 1994·Journal of Biomedical Materials Research·I M KangasniemiK de Groot
Dec 1, 1993·Acta Orthopaedica Scandinavica·J T HeikkiläR P Happonen
Jul 1, 1991·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·T NoguchiY Ikada

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Citations

Feb 6, 2004·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Mei Wang, Changlong Yu
Jun 5, 2003·The Journal of Bone and Joint Surgery. American Volume·Ken N KuoAlexander Templeton
Feb 4, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P A MouthuyZ Cui
Mar 23, 2007·Journal of Biomedical Materials Research. Part a·Hiroyuki KariyaYasuo Suda
Aug 10, 2010·Journal of Biomedical Materials Research. Part a·Hiroyuki KariyaYasuo Suda
Jun 12, 2013·Journal of Tissue Engineering and Regenerative Medicine·P-A MouthuyH Ye
May 7, 2009·Annals of Biomedical Engineering·Cristiano SpadaccioJorge A Genovese
Jan 22, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·B Sonny BalJames L Cook
Mar 17, 2018·Journal of Functional Biomaterials·Elisa FiumeFrancesco Baino
Feb 3, 2009·Calcified Tissue International·K YagihashiS Goto
Dec 22, 1999·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M A SuckowS F Badylak
Jan 5, 2002·Journal of Biomedical Materials Research·Takashi HisatomeYoshinori Fujimoto
Dec 25, 2012·The Journal of Surgical Research·Iris SchleicherReinhard Schnettler
Sep 14, 2000·Biomaterials·A Carranza-BencanoM A Lozano
Jul 17, 2012·Journal of Applied Biomaterials & Functional Materials·Bárbara J M Leite FerreiraRui Nunes Correia

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