May 30, 2016

Subchondral bone sclerosis and cancellous bone loss following OA induction depend on the underlying bone phenotype

Joint, Bone, Spine : Revue Du Rhumatisme
Anja OsterbergBrigitte Müller-Hilke

Abstract

Osteoarthritis (OA) is increasingly considered a disease of the whole joint, yet the interplay between the articular cartilage and the subchondral bone remains obscure. We here set out to investigate the impact of bone mass on the progression of surgically induced knee OA in the mouse. OA was induced in the right knees of female C57BL/6 (low bone mass) and STR/ort (high bone mass) mice via anterior cruciate ligament transection and destabilization of the medial meniscus. At 36 weeks of age, left and right knee joints were histologically compared for cartilage degeneration and via microCT analysis for subchondral bone plate thickness. In addition, femora were analyzed for bone mass at diaphysis and distal meta- and epiphysis. The severity of cartilage deterioration did not differ under high and low bone mass conditions. However, the extent of bone sclerosis differed and was proportional to the baseline subchondral bone plate thickness. Moreover, the cancellous bone loss following OA progression was inversely related to the bone mass: high bone mass restricted the loss to the epiphysis, whereas low bone mass allowed for a more widespread loss extending into the metaphysis. Our results suggest that cartilage degeneration is indepe...Continue Reading

Mentioned in this Paper

Diaphyses
Metaphysis
Trabecular Substance of Bone
TNFSF11
Transection
Meta Analysis (Statistical Procedure)
Degenerative Polyarthritis
Articular System
C57BL/6 Mouse
Impacted Tooth

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