Subchondroplasty for the treatment of post-traumatic bone marrow lesions of the medial femoral condyle in a pre-clinical canine model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Olubusola A BrimmoJames L Cook

Abstract

This study characterizes long-term outcomes associated with subchondroplasty (SCP) treatment for impact-induced subchondral bone marrow lesions (BML) using a validated pre-clinical canine model. With IACUC approval, purpose-bred research hounds (n = 16) underwent arthroscopic impact injury (40N) to both medial femoral condyles. At 3 months, functional assessments, arthroscopy, and MRI were performed and knees (n = 32) were randomly assigned to SCP (3 ml fluoroscopically guided percutaneous injection of AccuFill BSM into BML bone defects) or sham injection (Control). Dogs were assessed at 3, 6, 12, and 24 months after treatment using functional assessments, radiographic evaluation, arthroscopy, and MRI. Dogs were humanely euthanatized at 3, 6, 12, or 24 months after treatment for gross, microCT, and histologic assessments. All knees had focal articular cartilage defects with associated subchondral BMLs, as well as clinical dysfunction, 3 months after injury. At the 3 and 6 months, SCP knees showed more functional impairment than Control knees, however, these differences were not statistically significant. At 1- and 2-year post-treatment, function in SCP knees was better than in Control knees with range of motion being significan...Continue Reading

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Citations

Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Harvey A OliverJames L Cook
Mar 22, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anna J SchreinerJames L Cook
Jul 17, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Anna J SchreinerJames L Cook
Sep 30, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Leah N NairnMoin Khan
Jun 7, 2019·World Journal of Stem Cells·Akari SasakiIchiro Sekiya

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