Subchronic exposure to a mixture of groundwater-contaminating metals through drinking water induces oxidative stress in male rats

Environmental Toxicology and Pharmacology
S H JadhavH C Tripathi


The current study examines the oxidative stress-inducing potential of a mixture of metals, representative of groundwater contamination in different areas of India. Male albino rats were exposed to the mixture through drinking water for 90 days at 0, 1, 10 and 100 times the mode concentrations of the metals in contaminated waters and at concentrations equal to their WHO maximum permissible limit (MPL) in drinking water. The endpoints evaluated were lipid peroxidation (LPO), GSH content and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase in heart, liver, kidney and brain. MPL and 1× levels did not induce any alterations. The mixture at 10× and 100× doses increased LPO and decreased GSH level and activities of the antioxidases in kidney, liver and brain, but no alterations were observed in heart. An inverse correlation between LPO and GSH or antioxidaes and a positive correlation between GSH and glutathione peroxidase or glutathione reductase were found in the affected organs. The findings suggest that the mixture induces oxidative stress and decreases antioxidant status in 10× and 100× the mode concentrations of the metals in drinking water.


Jul 15, 1991·Biochemical Pharmacology·A GyurasicsZ Gregus
Jul 1, 1991·Archives of Biochemistry and Biophysics·P M ChungH F Gilbert
Feb 1, 1985·Analytical Biochemistry·A J Alpert, H F Gilbert
Dec 1, 1981·Archives of Biochemistry and Biophysics·P M Sinet, P Garber
Jan 1, 1983·Journal of Molecular Evolution·R N OndarzaM Ondarza
Jun 1, 1984·Toxicology Letters· Shafiq-Ur-Rehman
Apr 1, 1995·Biological Trace Element Research·R Sandhir, K D Gill
May 1, 1996·Biological Trace Element Research·Y L HuangT H Lin
May 1, 1997·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·S HussainS F Ali
Oct 29, 1997·Archives of Biochemistry and Biophysics·M Madesh, K A Balasubramanian
Jul 24, 1998·Biological Trace Element Research·M E DruyanW Marquardt
Aug 27, 1999·Toxicology·V N Adonaylo, P I Oteiza
Jan 13, 2000·Journal of Toxicology and Environmental Health. Part a·C Y ChenT H Lin
Jun 8, 2001·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·S J StohsM Bagchi
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edward J Calabrese
Sep 27, 2002·Toxicology·Debasis BagchiHarry G Preuss
Oct 9, 2002·Toxicology Letters·Sukumar ChattopadhyayShyamal Das Gupta
Apr 25, 2003·Archives of Environmental Contamination and Toxicology·N Aykin-BurnsN Ercal
Jun 7, 2003·Toxicology and Applied Pharmacology·Chang-Yu ChenYu-Tyng Huang
Feb 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Bruce A FowlerXue-Qing Chen
May 17, 2005·Current Medicinal Chemistry·M ValkoM T D Cronin

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