Subchronic Exposure to Arsenic Represses the TH/TRβ1-CaMK IV Signaling Pathway in Mouse Cerebellum

International Journal of Molecular Sciences
Huai GuanFengyuan Piao

Abstract

We previously reported that arsenic (As) impaired learning and memory by down-regulating calmodulin-dependent protein kinase IV (CaMK IV) in mouse cerebellum. It has been documented that the thyroid hormone receptor (TR)/retinoid X receptor (RXR) heterodimer and thyroid hormone (TH) may be involved in the regulation of CaMK IV. To investigate whether As affects the TR/RXR heterodimer and TH, we determined As concentration in serum and cerebellum, 3,5,3'-triiodothyronine (T3) and thyroxin (T4) levels in serum, and expression of CaMK IV, TR and RXR in cerebellum of mice exposed to As. Cognition function was examined by the step-down passive avoidance task and Morris water maze (MWM) tests. Morphology of the cerebellum was observed by Hematoxylin-Eosin staining under light microscope. Our results showed that the concentrations of As in the serum and cerebellum of mice both increased with increasing As-exposure level. A significant positive correlation was found between the two processes. Adeficit in learning and memory was found in the exposed mice. Abnormal morphologic changes of Purkinje cells were observed in cerebellum of the exposed mice. Moreover, the cerebellar expressions of CaMK IV protein and the TRβ gene, and TRβ1 prote...Continue Reading

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Citations

Apr 18, 2019·The Journal of Clinical Endocrinology and Metabolism·Xiaojie SunYuanyuan Li
Aug 20, 2019·Metabolic Brain Disease·Soheila AlboghobeishMohsen Rezaei
May 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ali Asghar HemmatiAkram Ahangarpour
Mar 13, 2021·Advanced Therapeutics·Carlisle R DeJuliusCraig L Duvall
May 1, 2021·International Journal of Molecular Sciences·Kinga SałaciakKarolina Pytka
Jun 6, 2021·Reviews on Environmental Health·Adeleh EsformAli Naghizadeh

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Methods Mentioned

BETA
protein assay

Software Mentioned

NoldusEthovision

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