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Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association

Mar 1, 2008

Warren D JohnsonDavid L McCormick

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Abstract

Se-methylselenocysteine (MSC) is an organoselenium compound being developed for breast cancer chemoprevention. To characterize MSC toxicity, CD rats received daily gavage doses of 0, 0.5, 1.0, or 2.0 mg/kg/day (0, 3, 6, or 12 mg/m(2)/day), and beagle dogs received daily gavage doses of ...read more

Mentioned in this Paper

Compound A 12
Hematology (Discipline)
Enzymes, antithrombotic
Selenium supplement
Enzymes, peripheral vasodilators
Blood Specimen
Selenomethylselenocysteine, (L)-isomer, 75Se-labeled
Entire Ovary
Dipstick Assessment of Hemoglobin Concentration
Benign Neoplasm of Thymus
Paper Details
References
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  • Citations12
123
  • References21
  • Citations12
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Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association

Mar 1, 2008

Warren D JohnsonDavid L McCormick

PMID: 18082924

DOI: 10.1016/j.fct.2007.11.001

Abstract

Se-methylselenocysteine (MSC) is an organoselenium compound being developed for breast cancer chemoprevention. To characterize MSC toxicity, CD rats received daily gavage doses of 0, 0.5, 1.0, or 2.0 mg/kg/day (0, 3, 6, or 12 mg/m(2)/day), and beagle dogs received daily gavage doses of ...read more

Mentioned in this Paper

Compound A 12
Hematology (Discipline)
Enzymes, antithrombotic
Selenium supplement
Enzymes, peripheral vasodilators

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References21
  • Citations12
123
  • References21
  • Citations12
12

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