Subchronic toxicity of Di(2-ethylhexyl)phthalate in common marmosets: lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia

Toxicological Sciences : an Official Journal of the Society of Toxicology
Y KurataM Katoh

Abstract

To evaluate the toxicological effect, di(2-ethylhexyl)phthalate (DEHP) was administered orally at 100, 500, and 2500 mg/kg to four male and four female marmosets in each group for 13 weeks. Its potentials of hepatic peroxisome proliferation, testicular atrophy, and pancreatic acinar cell hyperplasia were evaluated more closely. Clofibrate, which potently causes peroxisome proliferation in rodents, was administered in like manner at 250 mg/kg as a reference drug. DEHP induced significant suppression of weight gain in males at 2500 mg/kg. However, the increase in liver mass and hypertrophy of hepatocytes were not detected in organ weight measurements or histopathological examination. The number of peroxisomes, volume density, peroxisome morphology, and peroxisomal enzyme activities were not different from those in the control group, though the males treated with 500 and 2500 mg/kg DEHP showed 1.3- and 1.4-fold increases in mean peroxisome volume, respectively. In contrast, clofibrate induced 2.2 (in male)- and 1.9-fold (in female) increases in hepatic cyanide-insensitive acyl CoA oxidation system activity, 1. 2 (in male)- and 1.7-fold (in female) increases in hepatic carnitine-dependent acetyltransferase activity, and 1.8 (in mal...Continue Reading

Citations

Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chris E TalsnessFrederick S vom Saal
Oct 20, 2005·Occupational and Environmental Medicine·R Hauser, A M Calafat
Dec 3, 2014·Molecular and Cellular Endocrinology·Jose R Rodriguez-SosaIna Dobrinski
Feb 2, 2012·The Journal of Toxicological Sciences·Yoshimasa KurataMasanobu Katoh
Apr 3, 2012·The Journal of Toxicological Sciences·Yoshimasa KurataMasanobu Katoh
Jun 22, 2000·Toxicologic Pathology·R Nilsson
Dec 28, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hiroshi IwataHiroshi Yamazaki
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Sep 7, 2006·Critical Reviews in Toxicology·Ivan RusynMichael L Cunningham
Jan 20, 2004·Critical Reviews in Toxicology·James E KlaunigPenelope A Fenner-Crisp
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Sang Won HanByung Mu Lee

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