Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome

Journal of Neuroimmunology
B C JacobsN Yuki

Abstract

In 176 patients with Guillain-Barré syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG1 antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C. jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome.

References

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Citations

Oct 14, 2008·Lancet Neurology·Pieter A van DoornBart C Jacobs
Nov 16, 2013·Lancet Neurology·Satoshi Kuwabara, Nobuhiro Yuki
Dec 6, 2011·Journal of Medical Case Reports·Fotinie NtzioraKostas Konstantopoulos
Feb 23, 2012·Molecular Biotechnology·Francesca MarottaElisabetta Di Giannatale
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Pieter A van Doorn
Oct 10, 2015·Mediators of Inflammation·Ying WangHong-Liang Zhang
Mar 10, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pierre R BourqueRami Massie
Mar 8, 2016·Lancet·Hugh J WillisonPieter A van Doorn
Jun 29, 2018·Human Vaccines & Immunotherapeutics·Shuang LiuEroboghene Ekamereno Ubogu
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Marieke J H J DekkerBart C Jacobs
Jun 22, 2011·Nature Reviews. Neurology·Nortina Shahrizaila, Nobuhiro Yuki
Apr 8, 2019·Journal of Neurology·Michiaki KogaTakashi Kanda
Dec 8, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Meysam AbolmaaliZahra Mirzaasgari

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