PMID: 6966310Apr 1, 1980Paper

Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency

The Journal of Experimental Medicine
J SlackJ M Davie

Abstract

Antigens have been classified previously into three categories, thymus-dependent (TD), thymus-independent type (TI) 1, and TI-2, based upon thymic dependence and ability to stimulate an immunodeficient strain of mouse, CBA/N. Here we demonstrate that the different antigen classes elicit IgG antibodies of different subclasses. TD antigens stimulate predominantly IgG1 antibodies, with smaller amounts of IgG2 and IgG3 being expressed. TI-1 antigens stimulate almost no IgG1 antibodies and equal amounts of IgG2 and IgG3. TI-2 antigens elicit predominantly IgG3 antibodies. Mice expressing the CBA/N phenotype are known to be nonresponsive to TI-2 antigens. This was confirmed in this study. In addition, we demonstrate that the IgG3 component of the response to TI-1 antigens is virtually absent in mice expressing the CBA/N phenotype, which supports our previous finding that the CBA/N defect may be restricted to a B-lymphocyte subpopulation containing most of the precursors of IgG3-secreting cells.

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Citations

Sep 30, 1982·Journal of Immunological Methods·T Francus, G W Siskind
May 26, 1993·Journal of Immunological Methods·G MazzaA H Whiting
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·G M LewisJ H Slack
Mar 1, 1983·Molecular Immunology·H O SarvasO Mäkelä
May 1, 1995·Molecular Immunology·K A BrorsonK E Stein
May 1, 1992·Immunology Today·N S Greenspan, L J Cooper
May 1, 1991·Human Immunology·M B BowenM H Nahm
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Arturo Casadevall, Alena Janda
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T FrancusC G Becker
Jul 1, 1980·The Journal of Experimental Medicine·G P Der BalianJ M Davie
Nov 1, 1980·The Journal of Experimental Medicine·J Fung, H Köhler
Jan 1, 1981·The Journal of Experimental Medicine·P K MonginiW E Paul
Mar 1, 1982·The Journal of Experimental Medicine·P C IsaksonP H Krammer
Mar 1, 1983·The Journal of Experimental Medicine·L HangF J Dixon
Sep 1, 1983·The Journal of Experimental Medicine·M H NahmJ M Davie
Nov 1, 1983·The Journal of Experimental Medicine·F IvarsA Coutinho
Dec 1, 1984·The Journal of Experimental Medicine·J E LaytonP H Krammer
Jan 1, 1987·The Journal of Experimental Medicine·J P CoutelierJ Van Snick
Feb 1, 1987·The Journal of Experimental Medicine·L W Duran, E S Metcalf
Apr 1, 1996·The Journal of Experimental Medicine·G NussbaumM D Scharff

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