Subclassification of fatty liver by its pathogenesis: cIEFing is believing

The Journal of Pathology
Frances L Byrne, Kyle L Hoehn

Abstract

Fatty liver, also termed hepatic steatosis or fatty liver disease, is a condition characterized by excess fat accumulation in the liver. Common causes of fatty liver include obesity, ageing, medications, genetic disorders, viral hepatitis, excess alcohol or toxins. This diversity in pathogenesis is matched by an equally diverse spectrum of consequences, whereby some individuals remain asymptomatic yet others progress through a series of inflammatory, fibrotic and metabolic disorders that can lead to liver failure, cancer or diabetes. Current treatment approaches for fatty liver do not differ by disease aetiology and primarily involve weight loss strategies or management of co-morbidities. In a recent paper published in this journal, Urasaki et al used capillary isoelectric focusing (cIEF) to create profiles of protein post-translational modifications that distinguish four different models of fatty liver in mice. Importantly, this new cIEF approach has the potential to provide rapid individualized diagnosis of fatty liver pathogenesis that may enable more accurate and personalized treatment strategies. Further testing and optimization of cIEF as a diagnostic screening tool in humans is warranted.

References

Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Giulio MarchesiniGabriele Forlani
Nov 13, 2010·World Journal of Gastroenterology : WJG·Elizabeth M Brunt, Dina G Tiniakos
May 10, 2012·Therapeutic Advances in Gastroenterology·Jacob M KneemanKathleen E Corey
Sep 23, 2014·BMJ : British Medical Journal·Naveed SattarDavid Preiss
May 6, 2015·World Journal of Hepatology·Shehab M Abd El-Kader, Eman M Salah El-Den Ashmawy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.