Subclinical atherosclerosis after heart and heart-lung transplantation in childhood

Pediatric Transplantation
Robert Dalla PozzaHeinrich Netz

Abstract

Children after heart transplantation are considered as at-risk patients for extracardiac atherosclerotic complications. Noninvasive ultrasound measurement of the common carotid artery (IMT) provides valid information about the endothelial structure of the vascular system. Twenty-two patients (17 male, mean age 12.4 +/- 4.5 yr) after heart and (5.7 +/- 4.5 yr) heart-lung transplantation were enrolled. The mean IMT was measured and compared with a control group (18 children, 10 male, mean age 11.8 +/- 1.8 yr) and to normative data. Transplanted children had a higher IMT than controls (0.453 +/- 0.003 vs. 0.424 +/- 0.002 mm, p < 0.001). IMT-SDS was increased as well (1.6 +/- 0.1 vs. 0.8 +/- 0, p < 0.001). Transplanted children had a higher LDL/HDL-ratio (2.2 +/- 0.2 vs. 1.2 +/- 0.1, p < 0.001). Time after transplantation, age at the time of transplantation, or medical therapy did not influence the findings. We found evidence for subclinical atherosclerosis in children after heart and heart-lung transplantation. Even if single atherosclerotic risk factors could not be identified, transplanted children seem to be at risk for atherosclerosis. Our findings support the recently published statement of the AHA-Expert panel: after heart t...Continue Reading

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Citations

Jan 12, 2016·Pediatric Transplantation·Emilie RoblinAlain Lachaux
Nov 29, 2008·Pediatric Transplantation·Christian BendenStephen D Marks
Dec 3, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Elif Seda Selamet TierneySteven D Colan
Jan 25, 2020·Journal of the American Heart Association·Angela C ChenElif Seda Selamet Tierney

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