Subclinical atherosclerosis and obesity phenotypes among Mexican Americans

Journal of the American Heart Association
Susan T LaingSusan P Fisher-Hoch

Abstract

Data on the influence of obesity on atherosclerosis in Hispanics are inconsistent, possibly related to varying cardiometabolic risk among obese individuals. We aimed to determine the association of obesity and cardiometabolic risk with subclinical atherosclerosis in Mexican-Americans. Participants (n=503) were drawn from the Cameron County Hispanic Cohort. Metabolic health was defined as <2 of the following: blood pressure ≥130/85; triglyceride ≥150 mg/dL; high-density lipoprotein cholesterol <40 mg/dL (men) or <50 mg/dL (women); fasting glucose ≥100 mg/dL; homeostasis model assessment of insulin resistance value >5.13; or high-sensitivity C-reactive protein >3 mg/L. Carotid intima media thickness (cIMT) was measured. A high proportion of participants (77.8%) were metabolically unhealthy; they were more likely to be male, older, with fewer years of education, and less likely to meet daily recommendations regarding fruit and vegetable servings. One-third (31.8%) had abnormal carotid ultrasound findings. After adjusting for covariates, mean cIMT varied across the obesity phenotypes (P=0.0001); there was no difference among the metabolically unhealthy regardless of whether they were obese or not. In multivariable analysis, after a...Continue Reading

References

Jul 1, 1972·Journal of Chronic Diseases·A KeysH L Taylor
Mar 3, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K M FlegalC L Johnson
Nov 4, 2000·The American Journal of Clinical Nutrition·R J Kuczmarski, K M Flegal
Mar 31, 2001·The British Journal of Nutrition·P Deurenberg
Mar 15, 2002·The New England Journal of Medicine·Ranjana SinhaSonia Caprio
Mar 26, 2003·Cardiovascular Drugs and Therapy·Michiel L Bots, D Egbertus Grobbee
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Oct 12, 2004·Clinics in Dermatology·Philip T James
Apr 26, 2005·Social Science & Medicine·Barbara A Zsembik, Dana Fennell
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Dec 6, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Michio Shimabukuro
Apr 2, 2009·The International Journal of Behavioral Nutrition and Physical Activity·Adrian BaumanUNKNOWN IPS Group
May 23, 2009·Journal of the American College of Cardiology·Carl J LavieHector O Ventura
Jan 19, 2012·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Apr 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Mark Hamer, Emmanuel Stamatakis
Sep 6, 2012·European Heart Journal·Francisco B OrtegaSteven N Blair
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 11, 2013·Journal of Obesity·C M DurwardS M Nickols-Richardson
Mar 16, 2013·Diabetes Care·Sarah L AppletonUNKNOWN North West Adelaide Health Study Team
Aug 21, 2013·American Journal of Public Health·Ryan K MastersBruce G Link
Nov 22, 2013·The Journal of Clinical Endocrinology and Metabolism·KoKo AungSteven M Haffner
Jan 21, 2014·Progress in Cardiovascular Diseases·Vaughn W BarrySteven N Blair
Feb 18, 2014·Journal of the American College of Cardiology·Carl J LavieSteven N Blair
May 17, 2014·American Journal of Public Health·Saeideh Fallah-FiniThomas A Glass

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Citations

Nov 13, 2015·Expert Review of Cardiovascular Therapy·Naga V A KommuriLuis Afonso
Feb 18, 2016·Journal of Diabetes Research·Shenghui WuJoseph B McCormick
Dec 17, 2015·Cardiovascular Ultrasound·Baoge Qu, Tao Qu
Aug 26, 2016·Preventing Chronic Disease·Gordon P WattSusan P Fisher-Hoch
Apr 8, 2017·International Journal of Environmental Research and Public Health·Lili XiaGuangliang Shan
Jan 29, 2019·Journal of Medical Systems·Ruth ReáteguiVíctor Duque
May 4, 2021·Infectious Disease Modelling·Kristina P VatchevaMaría Cristina Villalobos

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Methods Mentioned

BETA
X‐ray

Software Mentioned

SAS
Carotid Analyzer

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