Subclinical Atherosclerosis and Relationship With Risk Factors of Coronary Artery Disease in a Rural Population

The American Journal of the Medical Sciences
Hadii M MamuduMatthew J Budoff

Abstract

Annually, over 150,000 cardiovascular events occur among individuals <65 years old in the United States, including asymptomatic ones. Coronary artery calcium (CAC), a subclinical marker of coronary artery disease (CAD), enhances risk stratification among asymptomatic individuals. This study assessed the prevalence of CAC in a rural population and determined relationships between traditional risk factors for CAD and CAC scores. During January 2011 to December 2012, asymptomatic individuals from central Appalachia were screened for CAC in the largest tertiary cardiovascular institute. Based on Agatston scale, participants were grouped into 4 CAC scores: zero (CAC = 0), mild (CAC = 1-99), moderate (CAC = 100-399) and severe (CAC ≥ 400). Multinomial logistic regression was used to examine associations between potential risk factors of CAD and CAC score. Of 1,674 participants, 55.4% had positive CAC score (CAC > 0). Increasing age and being male were positively associated with higher CAC scores. Although there was significant association between mild CAC and hypertension and family history of CAD, moderate CAC was positively associated with smoking status. Except hypercholesterolemia and sedentary lifestyle, severe CAC was significa...Continue Reading

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Citations

Jun 19, 2016·Indian Heart Journal·Priya ChockalingamAnand Chockalingam
Aug 17, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Hadii M MamuduMatthew Budoff
Mar 16, 2017·BioMed Research International·Young-Joo KimChul-Hyun Kim
Jun 24, 2021·Revista da Associação Médica Brasileira·Isa Galvão RodriguesFrancisco Bandeira

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