Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
A BaragettiA L Catapano

Abstract

Abdominal obesity and hepatic steatosis are ectopic fat depots associated with Metabolic Syndrome (MetS). Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. Therefore we studied whether different ectopic fat markers, and EFT in particular, are associated with MetS and markers of subclinical cardiovascular disease. 868 subjects from the PLIC Study were included, EFT, aortic calcifications, carotid Intima-Media Thickness (c-IMT) and echocardiographic parameters were determined by ultrasound; extra-cardiac atherosclerotic lesions were defined in presence of plaques at both carotid and aortic levels. Hepatic steatosis degrees were defined according to a scoring system. Abdominal adiposity was determined using Dual X-ray Absorbimetry (DEXA). Independently from age, women showed higher EFT versus men (4.5 (0.20-9.00) mm vs 4.00 (0.10-8.00) mm, p = 0.013); EFT was thicker in post-menopausal women (independently from hormone-replacement therapy). EFT, liver steatosis and abdominal adiposity increased with MetS (p < 0.001). EFT was the only ectopic fat marker associated with cardiac dysfunction (OR = 1.340 [1.088-1.651 95% C.I., p = 0.006); liver steatosis and EFT were associa...Continue Reading

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Citations

Aug 2, 2017·European Journal of Preventive Cardiology·Andrea BaragettiAlberico L Catapano
Apr 13, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christine F KuperMarcel V W Wijnands
Jun 6, 2019·Stroke; a Journal of Cerebral Circulation·Elena OlmastroniAlberico Luigi Catapano
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Jul 28, 2020·Journal of Clinical Medicine·Andrea BaragettiLaura Calabresi
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Feb 27, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M RuscicaG D Norata

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