Subclinical cardiac abnormalities and kidney function decline: the multi-ethnic study of atherosclerosis.

Clinical Journal of the American Society of Nephrology : CJASN
Meyeon ParkCarmen A Peralta

Abstract

Clinical heart failure (HF) is associated with CKD and faster rates of kidney function decline. Whether subclinical abnormalities of cardiac structure are associated with faster kidney function decline is not known. The association between cardiac concentricity and kidney function decline was evaluated. This is a longitudinal study of 3866 individuals from the Multi-Ethnic Study of Atherosclerosis (2000-2007) who were free of clinical cardiovascular disease, with an estimated GFR (eGFR) ≥60 ml/min per 1.73 m(2) at baseline and 5 years of follow-up. Concentricity, a measurement of abnormal cardiac size, was assessed by magnetic resonance imaging and evaluated as a continuous measurement and in quartiles. GFR was estimated by creatinine (eGFRcr) and cystatin C (eGFRcys). The association of concentricity with annual eGFR decline, incident CKD, and rapid kidney function decline (>5% per year) was investigated using linear mixed models as well as Poisson and logistic regression, respectively. Analyses adjusted for demographics, BP, diabetes, and inflammatory markers. Median decline was -0.8 (interquartile range, -3.1, -0.5) by eGFRcr. Compared with the lowest quartile of concentricity, persons in the highest quartile had an addition...Continue Reading

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Citations

Jun 24, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Todd H DriverJoachim H Ix
Apr 29, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meyeon Park
Jul 19, 2017·Heart·Courtney Tuegel, Nisha Bansal
Sep 25, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nadine Khouzam, Katherine Wesseling-Perry
Aug 13, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Matthew DenkerUNKNOWN Chronic Renal Insufficiency Cohort Study Investigators
Jan 22, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Nisha BansalMichael Shlipak
Nov 19, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Gates ColbertS Susan Hedayati
Jan 31, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Wisit KaewputWisit Cheungpasitporn
Sep 2, 2020·Journal of Nephrology·Giacomo DeferrariEdoardo La Porta
May 18, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sahapab AnuwatmateeKwok Leung Ong

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