Subclinical dysthyroid optic neuropathy: tritan deficiency as an early sign of dysthyroid optic neuropathy.

The British Journal of Ophthalmology
Aylin Garip KueblerChristoph Hintschich

Abstract

The aim of this research was to investigate the subclinical findings of dysthyroid optic neuropathy (DON) and to look for early indicators for optic nerve compression in patients with Graves' orbitopathy. In this observational, retrospective study, the medical charts of 24 patients (32 eyes) with a diagnosis of DON between 2008 and 2019 were included. Our goal was to identify potential pathological signs in patients with DON prior to the definitive diagnosis of DON. We discovered that the earliest pathological sign in the subclinical cases was tritan deficiency obtained with a standardised colour vision test by Arden. In all cases but one, regardless of the visual field (VF) defects, the tritan values were pathological (based on a threshold of ≥8%) in the subclinical phase. The mean tritan value was 19.12% (range 6.9-80.8%) at the time of the subclinical phase and 32.16% (range 6.3-100.0%) at the time of the diagnosis of DON. The sensitivity of the colour vision test was 20% for protan and 96.67% for tritan in the subclinical phase. At the time of the definitive diagnosis of DON, the sensitivity of protan was 48.15% compared to 96.30% for tritan. We found that changes in vision affecting the blue-yellow (tritan) colours resulti...Continue Reading

References

Nov 1, 1988·Ophthalmology·J M NeigelJ A Spinelli
Jul 1, 1987·Survey of Ophthalmology·W M Hart
Aug 17, 1999·Klinische Monatsblätter für Augenheilkunde·T BerningerA Kampik
May 14, 2003·Archives of Ophthalmology·John L KeltnerUNKNOWN Ocular Hypertension Treatment Study Group
Jun 19, 2003·The British Journal of Ophthalmology·A S NeubauerT Berninger
Jan 1, 1963·Journal of the Optical Society of America·G VERRIEST
Oct 13, 2006·The British Journal of Ophthalmology·David McKeagUNKNOWN European Group on Graves' Orbitopathy (EUGOGO)
Apr 5, 2011·Military Medicine·Jeff RabinMichelle Aaron
Jun 13, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ruth Huna-BaronZohar Habot-Wilner
Feb 15, 2014·International Ophthalmology·Ebrahim JafarzadehpurAkbar Fotouhi
Dec 15, 2015·Survey of Ophthalmology·Matthew P Simunovic
Mar 24, 2017·British Medical Bulletin·J L Barbur, M Rodriguez-Carmona

❮ Previous
Next ❯

Citations

Jun 24, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aylin Garip KueblerChristoph Hintschich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Aylin Garip KueblerChristoph Hintschich
The British Journal of Ophthalmology
David McKeagEuropean Group on Graves' Orbitopathy (EUGOGO)
La Revue lyonnaise de médecine
B Chatin, F Odelin
Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Maureen NeitzRigmor C Baraas
© 2021 Meta ULC. All rights reserved