Abstract
Recent studies suggest a close relationship between renal dysfunction and new onset diabetes (NOD). The aim of the study was to investigate the association between subclinical functional and structural renal abnormalities and NOD in primary hypertension (PH). This observational prospective study (9.1 ± 2.2 years follow-up) includes 231 consecutive untreated non-diabetic patients with PH and without overt nephropathy. The primary end point was NOD. Albuminuria (albumin to creatinine ratio, ACR), glomerular filtration rate (eGFR), and renal structure and hemodynamics (ultrasound scan and Doppler) were evaluated at baseline. During 2106 person-years of follow-up, 10 patients developed diabetes (incidence rate 4.7/1000 person-years). Patients with NOD showed a higher body mass index, serum uric acid, serum creatinine and ACR, and lower eGFR and renal volume (RV) to resistive index (RI) ratio (RV/RI) at baseline, as compared with the 221 controls that did not develop diabetes. When all renal variables were taken into consideration, RV/RI was the only variable significantly related to diabetes (hazard ratio 1.04, P=0.0342). Patients in the lowest tertile of RV/RI were more likely to develop diabetes (10.4 vs 2.6 vs 0%, P=0.0044). For...Continue Reading
References
Apr 1, 1994·Diabetes·L MykkänenM Laakso
Mar 9, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R PontremoliG Deferrari
Nov 13, 2002·Circulation·Scott M Grundy
Feb 6, 2004·Annals of Internal Medicine·Jing ChenJiang He
Sep 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ryota IkeeSoichiro Miura
Sep 28, 2005·Diabetes Care·Auke H BrantsmaUNKNOWN PREVEND Study Group
Feb 8, 2006·Annals of Internal Medicine·Mahboob RahmanUNKNOWN ALLHAT Collaborative Research Group
Jun 20, 2006·International Journal of Epidemiology·Zhiqiang Wang, Wendy E Hoy
Sep 8, 2006·Journal of Hypertension·Elena RattoRoberto Pontremoli
Feb 3, 2007·Diabetologia·S P O JanssonK Svärdsudd
Jul 3, 2007·Journal of the American College of Cardiology·Michael F O'Rourke, Junichiro Hashimoto
Dec 1, 2007·American Journal of Hypertension·Francesca ViazziRoberto Pontremoli
Mar 7, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Carlos LorenzoSteven M Haffner
Sep 26, 2008·Diabetologia·B CarstensenUNKNOWN Steering Group of the National Diabetes Register
Oct 16, 2008·Journal of Hypertension·Jean-Michel HalimiUNKNOWN DESIR Study Group
Apr 16, 2009·Diabetologia·C LorenzoS M Haffner
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 25, 2009·Diabetes Care·Satoru KodamaHirohito Sone
Oct 2, 2009·Metabolism: Clinical and Experimental·Baris AfsarFatma Nurhan Ozdemir
Feb 27, 2010·Diabetes Care·Shinji YasunoKazuwa Nakao
Mar 6, 2010·American Journal of Hypertension·Andrea BerniLoredana Poggesi
Jul 17, 2010·American Journal of Hypertension·Ju-Yi ChenJyh-Hong Chen
Oct 6, 2010·Diabetes Care·Francesca ViazziRoberto Pontremoli
Citations
Nov 1, 2013·Journal of Hypertension·Francesca ViazziRoberto Pontremoli
Aug 24, 2013·Thrombosis and Haemostasis·F CarboneF Viazzi
Sep 5, 2015·Internal and Emergency Medicine·Maria BoddiElisa Ciani
Sep 7, 2016·Diabetes & Metabolic Syndrome·Baris Afsar, Rengin Elsurer
Feb 13, 2014·European Journal of Preventive Cardiology·Giulio GeraciSantina Cottone
Jul 5, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Channabasappa ShivaprasadK M Prasanna Kumar
Apr 28, 2016·Journal of Hypertension·Francesca ViazziRoberto Pontremoli