Subclinical functional and structural renal abnormalities predict new onset type 2 diabetes in patients with primary hypertension

Journal of Human Hypertension
F ViazziR Pontremoli

Abstract

Recent studies suggest a close relationship between renal dysfunction and new onset diabetes (NOD). The aim of the study was to investigate the association between subclinical functional and structural renal abnormalities and NOD in primary hypertension (PH). This observational prospective study (9.1 ± 2.2 years follow-up) includes 231 consecutive untreated non-diabetic patients with PH and without overt nephropathy. The primary end point was NOD. Albuminuria (albumin to creatinine ratio, ACR), glomerular filtration rate (eGFR), and renal structure and hemodynamics (ultrasound scan and Doppler) were evaluated at baseline. During 2106 person-years of follow-up, 10 patients developed diabetes (incidence rate 4.7/1000 person-years). Patients with NOD showed a higher body mass index, serum uric acid, serum creatinine and ACR, and lower eGFR and renal volume (RV) to resistive index (RI) ratio (RV/RI) at baseline, as compared with the 221 controls that did not develop diabetes. When all renal variables were taken into consideration, RV/RI was the only variable significantly related to diabetes (hazard ratio 1.04, P=0.0342). Patients in the lowest tertile of RV/RI were more likely to develop diabetes (10.4 vs 2.6 vs 0%, P=0.0044). For...Continue Reading

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Citations

Nov 1, 2013·Journal of Hypertension·Francesca ViazziRoberto Pontremoli
Sep 5, 2015·Internal and Emergency Medicine·Maria BoddiElisa Ciani
Sep 7, 2016·Diabetes & Metabolic Syndrome·Baris Afsar, Rengin Elsurer
Feb 13, 2014·European Journal of Preventive Cardiology·Giulio GeraciSantina Cottone
Jul 5, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Channabasappa ShivaprasadK M Prasanna Kumar

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