Subclinical hypothyroidism and functional mobility in older adults.

Archives of Internal Medicine
Eleanor M SimonsickHealth ABC Study

Abstract

Health risks associated with subclinical hypothyroidism in older adults are unclear. Our objective was to compare the functional mobility of people aged 70 to 79 years by thyroid function categorized by thyrotropin (TSH) level as euthyroid (>or=0.4 to <4.5 mIU/L), mild subclinical hypothyroid (>or=4.5 to <7.0 mIU/L), or moderate subclinical hypothyroid (>or=7.0 to <or=20.0 mIU/L with a normal free thyroxine level) cross-sectionally and over 2 years. A total of 2290 community-dwelling residents participating in the year 2 clinic visit (July 1998-June 1999) of the Health, Aging, and Body Composition (Health ABC) Study, who had measured TSH level, had the capacity to walk 20 m unaided, and were not taking thyroid medication or had TSH levels consistent with hyperthyroidism or hypothyroidism. Main outcome measures included self-reported and performance-based measures of mobility (usual and rapid gait speed and endurance walking ability) assessed at study baseline (year 2) and 2 years later. In age- and sex-adjusted analyses, the mild subclinical hypothyroid group (vs the euthyroid group) demonstrated better mobility (faster mean usual and rapid gait speed [1.20 vs 1.15 m/s and 1.65 vs 1.56 m/s, respectively; P < .001] and had a hig...Continue Reading

References

Apr 1, 1995·The Netherlands Journal of Medicine·W M Wiersinga
Mar 2, 1995·The New England Journal of Medicine·J M GuralnikR B Wallace
Jul 23, 1998·The American Journal of Medicine·D C BauerW S Browner
Jan 12, 2001·Journal of the American College of Cardiology·H TanakaD R Seals
Oct 5, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E M SimonsickUNKNOWN Health ABC Study Group
Mar 14, 2002·Journal of the American Geriatrics Society·E M SimonsickT Harris
Jan 22, 2004·Annals of Internal Medicine·Mark Helfand, UNKNOWN U.S. Preventive Services Task Force
Sep 1, 2004·Annals of Family Medicine·William J Hueston, William S Pearson
Dec 2, 2004·JAMA : the Journal of the American Medical Association·Jacobijn GusseklooRudi G J Westendorp
Dec 2, 2004·JAMA : the Journal of the American Medical Association·David S Cooper
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Annewieke W van den BeldSteven W J Lamberts
Nov 30, 2005·Archives of Internal Medicine·Nicolas RodondiDouglas C Bauer
Dec 14, 2005·Clinical Endocrinology·John P WalshValdo Michelangeli
Jan 20, 2006·Journal of the American Geriatrics Society·Eleanor M SimonsickJerome L Fleg
Mar 2, 2006·JAMA : the Journal of the American Medical Association·Anne R CappolaPaul W Ladenson
May 4, 2006·JAMA : the Journal of the American Medical Association·Anne B NewmanTamara B Harris
May 16, 2006·Journal of the American Geriatrics Society·Subashan PereraStephanie A Studenski
Jan 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoyuki TakashimaNaoharu Iwai
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
May 21, 2008·Annals of Internal Medicine·Nicolas OchsNicolas Rodondi
May 29, 2008·The Journal of Clinical Endocrinology and Metabolism·Salman RazviSimon H S Pearce
Jul 22, 2008·Psychoneuroendocrinology·Eef HogervorstCarol Brayne
Dec 5, 2008·Journal of the American Geriatrics Society·Graziano CeresiniLuigi Ferrucci

❮ Previous
Next ❯

Citations

Oct 23, 2013·European Journal of Endocrinology·Francesc FormigaUNKNOWN Octabaix Study Group
Aug 15, 2013·Thyroid : Official Journal of the American Thyroid Association·Vanessa S VirginiUNKNOWN PROSPER Study Group
Oct 10, 2013·Journal of Thyroid Research·Naveen Aggarwal, Salman Razvi
Nov 2, 2013·Endocrine·Silvana Oliveira E SilvaPatricia de Fatima Dos S Teixeira
Aug 8, 2013·British Medical Bulletin·Anukul Garg, Mark P J Vanderpump
Oct 1, 2014·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasUNKNOWN American Thyroid Association Task Force on Thyroid Hormone Replacement
Mar 25, 2014·Asian Journal of Psychiatry·Gaurav VishnoiBinita Goswami
Sep 10, 2010·International Journal of Biological Sciences·Scott A HelmsJeanne Y Wei
May 3, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Yee Yung NgWu Chang Yang
Jun 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lily L SomwaruAnne R Cappola
Jan 2, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Jean-Claude Lapraz, Kamyar M Hedayat
May 25, 2013·Endocrinology and Metabolism Clinics of North America·W Edward VisserRobin P Peeters
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Bernadette Biondi
Jan 26, 2012·Lancet·David S Cooper, Bernadette Biondi
Mar 18, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gerald J JeromeEleanor M Simonsick
Jan 29, 2011·Journal of Intellectual Disability Research : JIDR·V PrasherS Haque
Jan 15, 2014·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Oct 24, 2014·Frontiers in Endocrinology·Sara TogniniFabio Monzani
Aug 21, 2014·Research Quarterly for Exercise and Sport·Jeannette A C LankhaarFrank J G Backx
Jun 3, 2016·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Jan 23, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eleanor M SimonsickLuigi Ferrucci
Jul 30, 2015·Archives of Endocrinology and Metabolism·Dhiãnah Santini de Oliveira ChachamovitzPatricia de Fátima Dos Santos Teixeira
Jun 29, 2017·The New England Journal of Medicine·Robin P Peeters
Feb 18, 2016·Therapeutic Advances in Endocrinology and Metabolism·Zeeshan Javed, Thozhukat Sathyapalan
Feb 9, 2011·Nature Reviews. Endocrinology·Peter LaurbergInge Bülow Pedersen
Feb 27, 2013·Nature Reviews. Endocrinology·Kristien Boelaert
Jan 28, 2015·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Wendy P J den ElzenJacobijn Gussekloo
Jul 17, 2010·American Journal of Therapeutics·Arshag D Mooradian
Jul 18, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoUNKNOWN Italian Section of the European Ligand Assay Society (ELAS)
Jan 18, 2014·Endocrine Reviews·Bernadette Biondi, Leonard Wartofsky
Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Simon H S PearceCarol Jagger
Dec 15, 2016·Scientific Reports·Arjola BanoRobin P Peeters
Jan 7, 2020·Korean journal of family medicine·Minjung HanSang Min Park
Jan 24, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Megan M MarronAnne B Newman
Mar 14, 2020·Journal of the American Geriatrics Society·Claudia SzlejfIsabela M Bensenor
Dec 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Tou-Yuan TsaiHuei-Kai Huang
Jul 7, 2020·Annals of Internal Medicine·Michael T McDermott
May 16, 2012·Arquivos brasileiros de endocrinologia e metabologia·Vaneska Spinelli ReutersMário Vaisman
May 18, 2013·Arquivos brasileiros de endocrinologia e metabologia·Jose A SgarbiUNKNOWN Brazilian Society of Endocrinology and Metabolism
Oct 27, 2015·The Journal of Clinical Endocrinology and Metabolism·Vanessa S VirginiUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Apr 8, 2016·Endocrine Journal·Dhiãnah Santini de Oliveira ChachamovitzPatrícia de F Dos S Teixeira

❮ Previous
Next ❯

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