Subclinical hypothyroidism, arterial stiffness, and myocardial reserve

The Journal of Clinical Endocrinology and Metabolism
P J D OwenJ H Lazarus

Abstract

Subclinical hypothyroidism (SCH) is associated with increased risk of cardiac disease; its impact on arterial function is less clear. The objective of the study was the assessment of arterial and cardiac function. The study was a 6-month controlled observational study using pulse wave analysis and tissue Doppler dobutamine stress echocardiography. The study was conducted at a thyroid clinic. Nineteen female SCH patients with raised TSH, normal free T(4), and no cardiovascular disease [aged 49.2 +/- 3.8 yr; body mass index (BMI) 29.9 +/- 6.7 kg/m(2)] were recruited from the thyroid clinic, and 10 female controls (aged 50.2 +/- 3.4 yr; BMI 29.7 +/- 7.2 kg/m(2)) also participated in the study. Incremental doses of l-thyroxine were used. Indices of vascular stiffness and left ventricular echocardiographic function were measured. Baseline augmentation gradient was elevated in SCH, compared with controls [10.3 +/- 5.1 (sd) mm Hg vs. 8.0 +/- 4.2, P < 0.05]; when euthyroid (mean T(4) dose 114 mug/d), it fell to 8.8 +/- 5.3 mm Hg (P < 0.05). Heart rate-corrected augmentation index was 26.7 +/- 9.9 vs. 18.8 +/- 9.9% (P < 0.02), falling to 19.7 +/- 9.6% (P < 0.001) after treatment. Time of travel of the reflected wave was 139.3 +/- 11.7 m...Continue Reading

Citations

May 1, 2007·Thyroid : Official Journal of the American Thyroid Association·John H Lazarus
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Penelope J D OwenJohn H Lazarus
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas, Leonard Wartofsky
Aug 19, 2007·Thyroid : Official Journal of the American Thyroid Association·Bernadette Biondi
Jul 25, 2008·Thyroid : Official Journal of the American Thyroid Association·Ronit Koren PelegAhuva Golik
Mar 10, 2010·Thyroid : Official Journal of the American Thyroid Association·Elizabeth N PearceRamachandran S Vasan
Feb 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Till IttermannHenry Völzke
Oct 11, 2011·Cardiology in Review·Irene A WeissWilliam H Frishman
Jan 10, 2012·Journal of Hypertension·Irene LambrinoudakiKimon Stamatelopoulos
Jul 17, 2010·American Journal of Therapeutics·Arshag D Mooradian
Jan 29, 2011·BMC Pregnancy and Childbirth·Simone M KuppensVictor J Pop
Nov 9, 2010·Vascular Health and Risk Management·Michael A MazzeffiDavid E DeLaet
Dec 1, 2009·Pakistan Journal of Biological Sciences : PJBS·M NiafarN Aghamohammadzadeh
Jun 10, 2014·Indian Journal of Endocrinology and Metabolism·Syed Abbas Raza, Nasir Mahmood
Sep 10, 2013·Journal of Laboratory Physicians·Abiodun Mathias EmokpaeHumphrey Benedo Osadolor
Aug 15, 2014·Current Cardiology Reports·Alejandro Velasco, Wanpen Vongpatanasin
Sep 23, 2014·Wiener klinische Wochenschrift·Fahri GunesErdem Akbal
Dec 23, 2011·Clinical Endocrinology·Avantika C WaringUNKNOWN Health, Ageing, and Body Composition (Health ABC) Study
Apr 4, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Mitsuru MasakiTohru Masuyama
Feb 28, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Connie M RheeKamyar Kalantar-Zadeh
Sep 17, 2016·American Journal of Hypertension·Érique José F Peixoto de MirandaIsabela J Martins Benseñor
Apr 14, 2017·Post Reproductive Health·Christopher Redford, Bijay Vaidya
Mar 2, 2018·European Journal of Endocrinology·Gisah Amaral de CarvalhoHans Graf
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
Jun 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Amjid IqbalRolf Jorde
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Giampaolo PapiElio Roti
May 1, 2010·Expert Review of Endocrinology & Metabolism·Vahab Fatourechi
Jan 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Bjørn O AsvoldLars J Vatten
Jun 13, 2017·Journal of Atherosclerosis and Thrombosis·Junichiro Hashimoto
Aug 6, 2019·Frontiers in Endocrinology·Eszter BertaMiklós Bodor
Sep 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Anne R Cappola

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Thyroid : Official Journal of the American Thyroid Association
C T Sawin
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Roy MoncayoKlaus Kapelari
Archives of Gerontology and Geriatrics
Valéria B ChueireLaura S Ward
© 2021 Meta ULC. All rights reserved