Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis

Thyroid : Official Journal of the American Thyroid Association
P H DesseinAnne E Stanwix

Abstract

We investigated the prevalence of subclinical hypothyroidism and its association with insulin resistance and other cardiovascular (CV) risk factors in rheumatoid arthritis (RA). We recorded thyroid function tests, insulin resistance markers comprising the Homeostasis Model Assessment for insulin resistance (HOMA-IR), the Quantitative Insulin Sensitivity Check Index (QUICKI) and triglycerides/high-density lipoprotein (HDL) cholesterol ratios, and other CV risk factors in 126 patients with RA. Fifteen (12%) were taking thyroxine for hypothyroidism and 14 (11%) had subclinical hypothyroidism (thyrotropin > 4 mU/L and normal free thyroxine levels). Compared to the 97 euthyroid patients, the QUICKI was lower and the HOMA-IR higher in treated (p = 0.031 for both) and subclinical (p = 0.004 for both) hypothyroid cases while the triglycerides/HDL cholesterol ratios were higher in subclinical (p = 0.039) but not in treated hypothyroid (p = 0.365) cases. Treated hypothyroid patients were more often hypertensive (n = 11 [75%]) than euthyroid patients (n = 36 [37%]) (p = 0.008). No other differences in characteristics were found among the three groups. After controlling for potentially confounding variables, subclinical hypothyroidism rema...Continue Reading

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Citations

Apr 2, 2009·Nature Reviews. Rheumatology·Mariana J Kaplan
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Gabriela BrentaLaura Schreier
Feb 21, 2006·Thyroid : Official Journal of the American Thyroid Association·Marina A MichalakiVenetsana E Kyriazopoulou
Dec 17, 2008·Thyroid : Official Journal of the American Thyroid Association·Shu-Chuan HuangWen-Dau Chang
Sep 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Jeffrey R GarberUNKNOWN American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults
Apr 4, 2006·Current Opinion in Rheumatology·Mariana J Kaplan
Aug 12, 2006·Endocrine Journal·Ahmed Al SayedEid Alfadhli
May 15, 2013·Journal of Diabetes Research·Chaoxun Wang
Jan 15, 2009·European Journal of Endocrinology·Eirini MaratouGeorge Dimitriadis
Sep 24, 2011·Journal of Thyroid Research·Gabriela Brenta
Feb 6, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·James V HennesseyUNKNOWN American College of Endocrinology (ACE)
Mar 31, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Laszlo OnodiGaspar Banfalvi
Jun 1, 2010·Rheumatic Diseases Clinics of North America·Mariana J Kaplan
Apr 9, 2008·Seminars in Arthritis and Rheumatism·George Steiner, Murray B Urowitz
Sep 2, 2006·Arthritis and Rheumatism·Patrick H Dessein, Barry I Joffe
Oct 1, 2005·Seminars in Arthritis and Rheumatism·Ahmed SolomonAnne E Stanwix
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Patrick H DesseinAnne E Stanwix
Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey R GarberUNKNOWN American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults
Jul 28, 2009·Arthritis Research & Therapy·Dimitrios DaoussisGeorge D Kitas
Aug 9, 2005·Seminars in Arthritis and Rheumatism·Miguel A Gonzalez-GayJavier Martin
Nov 21, 2007·Clinics in Dermatology·Enno Christophers
May 8, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yan-Fang Ren, Hans S Malmstrom
Feb 17, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Claudia M Campbell, Robert R Edwards
Jul 6, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gabriela BrentaUNKNOWN Task Force on Hypothyroidism of the Latin American Thyroid Society (LATS)
Nov 5, 2014·The Journal of Rheumatology·Raquel López-MejiasPatrick H Dessein
May 3, 2007·The Journal of Clinical Endocrinology and Metabolism·Henry VölzkeMarcus Dörr

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