Subclinical hypothyroidism might worsen the effects of aging on serum lipid profiles: a population-based case-control study

Thyroid : Official Journal of the American Thyroid Association
Meng ZhaoJiajun Zhao

Abstract

Dyslipidemia is an important global health problem, particularly in the elderly population. Traditionally, the high prevalence of dyslipidemia in elderly people is considered a "natural condition." Notably, subclinical hypothyroidism (SCH) is one of the most important risk factors for dyslipidemia. Few studies have assessed whether SCH plays a role in the increase in age-related dyslipidemia. This study aimed to explore the association between SCH and lipid profiles in different age groups. This was a large-scale, population-based, case-control study. The population was derived from the REACTION study conducted across China. A total of 17,046 individuals (8827 cases and 8219 controls) aged 40 years or older were enrolled in the final analyses. The relationships between SCH and serum lipid parameters in each age group were evaluated after adjustment for thyroid hormones and common confounding factors. In the entire population, thyrotropin (TSH), the key indicator of SCH, was positively associated with cholesterol parameters (total cholesterol [TC] and low-density lipoprotein cholesterol [LDL-C]) through the sixth decade of life. After adjusting for common confounding factors and thyroid hormones, each 1 mIU/L increase in TSH was...Continue Reading

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Citations

Jun 9, 2016·Thyroid : Official Journal of the American Thyroid Association·Meng ZhaoJiajun Zhao
Jun 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José María Moreno-NavarreteJosé Manuel Fernández-Real
Nov 16, 2019·Minerva medica·Alessandro P DelitalaGian Luca Erre
Apr 14, 2020·JAAPA : Official Journal of the American Academy of Physician Assistants·Chelsea SimonSarah Allen
Jan 31, 2020·Frontiers in Endocrinology·Angeliki StamatouliSahzene Yavuz
Sep 21, 2018·Frontiers in Endocrinology·Leonidas H Duntas, Gabriela Brenta
May 12, 2017·Irish Journal of Medical Science·F Decandia

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