Subclinical MRI disease activity influences cognitive performance in MS patients

Multiple Sclerosis and Related Disorders
Alfredo DamascenoFernando Cendes

Abstract

The pathological mechanisms underlying cognitive dysfunction in multiple sclerosis (MS) are not yet fully understood and, in addition to demyelinating lesions and gray-matter atrophy, subclinical disease activity may play a role. To evaluate the contribution of asymptomatic gadolinium-enhancing lesions to cognitive dysfunction along with gray-matter damage and callosal atrophy in relapsing-remitting MS (RRMS) patients. Forty-two treated RRMS and 30 controls were evaluated. MRI (3T) variables of interest were brain white-matter and cortical lesion load, cortical and deep gray-matter volumes, corpus callosum volume and presence of gadolinium-enhancing lesions. Outcome variables included EDSS, MS Functional Composite (MSFC) subtests and the Brief Repeatable Battery of Neuropsychological tests. Cognitive dysfunction was classified as deficits in two or more cognitive subtests. Multivariate regression analyses assessed the contribution of MRI metrics to outcomes. Patients with cognitive impairment (45.2%) had more cortical lesions and lower gray-matter and callosal volumes. Patients with subclinical MRI activity (15%) had worse cognitive performance. Clinical disability on MSFC was mainly associated with putaminal atrophy. The main ...Continue Reading

References

Nov 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·R O Barnard, M Triggs
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·J FoongM A Ron
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jun 24, 2008·Annals of Neurology·Leonora K FisnikuDavid H Miller
May 14, 2009·Multiple Sclerosis : Clinical and Laboratory Research·S D RoosendaalJ J G Geurts
Sep 16, 2009·Archives of Neurology·Massimiliano CalabreseMassimo Filippi
Oct 20, 2010·Multiple Sclerosis : Clinical and Laboratory Research·M KhalilF Fazekas
Jan 7, 2011·Neurology·J J G GeurtsUNKNOWN MAGNIMS Study Group
Mar 30, 2011·Neurology·M S A DeloireB Brochet
May 11, 2011·Nature Reviews. Neurology·Ralph H B Benedict, Robert Zivadinov
Nov 17, 2012·Lancet Neurology·Jeroen J G GeurtsRichard A Rudick
Apr 2, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Matteo PardiniLuca Roccatagliata
May 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Ralph Hb BenedictBianca Weinstock-Guttman

❮ Previous
Next ❯

Citations

Oct 4, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Alfredo DamascenoFernando Cendes
Feb 6, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Seyed-Parsa HojjatRichard I Aviv
Sep 21, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Myintzu MinJeannette Lechner-Scott
Oct 10, 2019·Revista latino-americana de enfermagem·Ana Railka de Souza Oliveira-KumakuraRenata Cristina Gasparino
Oct 12, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Alfredo DamascenoFernando Cendes
Jul 6, 2018·Brain and Behavior·Erica CurtiFranco Granella
Jun 11, 2020·Scientific Reports·Alejandra Figueroa-VargasPablo Billeke
Aug 20, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Matteo Pardini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.