Subclinical myopathy in patients affected with newly diagnosed colorectal cancer at clinical onset of disease: evidence from skeletal muscle biopsies

Neurological Research
S ZampieriS Merigliano

Abstract

To evaluate skeletal muscle biopsy from asymptomatic patients affected with newly diagnosed colorectal cancer and to identify pathological features which may be indicative of tumor-associated muscle disorders, potentially leading to cachexia. Patients affected with newly diagnosed colorectal cancer at clinical onset of disease underwent biopsy of the rectus abdominis muscle during elective laparoscopic tumor resection, before chemotherapeutic treatment. Morphometric analyses, ATPase histochemistry and immunohistochemical studies using antibodies directed to N-CAM and to MHC-emb, two sound makers of muscle denervation and injury-induced muscle regeneration, were performed on intraoperative muscle biopsies from ten patients. Muscle biopsies from rectus abdominis of seven subjects affected with non-neoplastic condition, which underwent laparoscopic surgery, were used as controls. In patients' biopsies, we observed a surprisingly high percentage of myofibers with internalized or central nuclei compared to controls (9.15 +/- 8.9 versus 0.6 +/- 0.9, p<0.0003). In addition, in the 30% of patients, small myofibers expressing the MHC-emb have been identified (0.4 +/- 0.5 positive fibers/mm(2)), while in 50% of patients, larger fibers po...Continue Reading

References

May 1, 1987·Journal of Neuropathology and Experimental Neurology·I MussiniU Carraro
Sep 8, 1984·British Medical Journal·P W EmeryD Halliday
Jan 1, 1995·Journal of Neuropathology and Experimental Neurology·M Cantini, U Carraro
Jan 21, 2000·The International Journal of Biochemistry & Cell Biology·M Sandri, U Carraro
Oct 19, 2004·Medical Hypotheses·Eric R BravermanMatthew Stanford
Jul 27, 2005·Journal of Neuropathology and Experimental Neurology·Christopher R PiersonAlan H Beggs
Aug 11, 2005·Rheumatology International·Csilla AndrásKatalin Dankó
Nov 17, 2005·Journal of Applied Physiology·Kristen A MehlJames A Carson
Jun 14, 2006·Autoimmunity·C BrianiM C Dalakas
Jun 14, 2006·Autoimmunity·Sandra ZampieriAndrea Doria
Sep 1, 2006·Pharmacopsychiatry·S Leucht, R Lasser
Jan 11, 2007·The Journal of Biological Chemistry·Helen L Eley, Michael J Tisdale
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·John A FaulknerSusan V Brooks
Nov 21, 2007·Oncology Nursing Forum·Rose Mary Carroll-Johnson
May 20, 2008·Autoimmunity Reviews·Vito RacanelliFederico Perosa
Aug 30, 2008·Autoimmunity Reviews·Andrea DoriaPiercarlo Sarzi-Puttini

❮ Previous
Next ❯

Citations

Apr 18, 2013·Current Rheumatology Reports·Anna GhirardelloAndrea Doria
Dec 31, 2010·Clinical Reviews in Allergy & Immunology·Anna GhirardelloAndrea Doria
Jan 10, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J F ChristensenP Hojman
Jan 20, 2016·Seminars in Cell & Developmental Biology·Iain J GallagherKenneth Fearon
May 23, 2015·Auto- Immunity Highlights·Anna GhirardelloAndrea Doria
Jun 19, 2013·The International Journal of Biochemistry & Cell Biology·N JohnsK C H Fearon
Aug 12, 2014·Frontiers in Aging Neuroscience·Helmut KernAntonio Musaro
Mar 13, 2014·Journal of Neuropathology and Experimental Neurology·Simone MosoleSandra Zampieri
Jul 16, 2019·Journal of Cachexia, Sarcopenia and Muscle·Ana Anoveros-BarreraVera C Mazurak
Feb 12, 2020·International Journal of Molecular Sciences·Nissrine DaouDario Coletti
Dec 1, 2013·Regenerative Medicine Research·Dario ColettiSergio Adamo
Aug 29, 2018·Oxidative Medicine and Cellular Longevity·Hilda Merino, Dinender K Singla
Dec 10, 2016·Frontiers in Physiology·Anna L Mazzotti, Dario Coletti
May 24, 2018·Cancer Prevention Research·Fernanda de Souza-TeixeiraVicente Martín
Mar 31, 2021·Journal of Cachexia, Sarcopenia and Muscle·Agnès Martin, Damien Freyssenet
Nov 4, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Madison E ColcordJonathan C Salo
Nov 5, 2010·Current Opinion in Supportive and Palliative Care
Oct 30, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.