PMID: 15345186Sep 4, 2004Paper

Subclinical neurophysiological effects of manganese in welding workers

International Journal of Immunopathology and Pharmacology
S C He, Qiao Niu

Abstract

High-level occupational manganese (Mn) exposure has been reported to induce irreversible brain alterations determining a Parkinson-like disease. This study aimed to assess subclinical neurophysiological alterations in welding workers. They were employed in a machine building factory with an average Mn exposure <200 mg/m3. Sixty-eight workers (mean age: 34 years; mean Mn exposure duration: 16 years) and 42 flour factory workers (control group) with similar age and smoking habit were recruited. Autonomic nervous function test battery (ANSFT), composed of Valsalva maneuvre-induced heart rate variation (HR-V), heart rate variation following deep breathing (HR-DB) and heart rate variation following immediate standing up (HR-IS) was assessed. Electroencephalogram (EEG), brain electricity activity mapping (BEAM) were also performed. HR-V, HR-DB, and HR-IS were significantly lower in Mn-exposed subjects showing altered autonomic nervous system activity, parasympathetic-sympathetic imbalance and, and consequently, altered cardiovascular regulation and reactivity. The EEG of the Mn-exposed workers evidenced beta-wave rhythms significantly reduced, theta-waves markedly increased and abnormal wave activities of either localized or diffusiv...Continue Reading

Associated Clinical Trials

References

Jan 1, 1991·International Archives of Occupational and Environmental Health·K TeruyaY Kaneko
Aug 1, 1991·Scandinavian Journal of Work, Environment & Health·A WennbergL Johansson
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Mar 15, 1993·Annals of Internal Medicine·C M van Ravenswaaij-ArtsH P van Geijn
Jan 1, 1997·Environmental Research·D Mergler, M Baldwin
Jun 19, 1998·Environmental Research·W W BarringtonT Korn
Feb 13, 2001·Environmental Research·M C DietzG Triebig

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Citations

Apr 18, 2012·International Journal of Immunopathology and Pharmacology·M PetriniG Spoto
Jan 30, 2016·Environmental Health Perspectives·Tongjian CaiJingyuan Chen

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