Subclinical recurrent neck pain and its treatment impacts motor training-induced plasticity of the cerebellum and motor cortex

PloS One
Julianne BaarbéBernadette Murphy

Abstract

The cerebellum processes pain inputs and is important for motor learning. Yet, how the cerebellum interacts with the motor cortex in individuals with recurrent pain is not clear. Functional connectivity between the cerebellum and motor cortex can be measured by a twin coil transcranial magnetic stimulation technique in which stimulation is applied to the cerebellum prior to stimulation over the motor cortex, which inhibits motor evoked potentials (MEPs) produced by motor cortex stimulation alone, called cerebellar inhibition (CBI). Healthy individuals without pain have been shown to demonstrate reduced CBI following motor acquisition. We hypothesized that CBI would not reduce to the same extent in those with mild-recurrent neck pain following the same motor acquisition task. We further hypothesized that a common treatment for neck pain (spinal manipulation) would restore reduced CBI following motor acquisition. Motor acquisition involved typing an eight-letter sequence of the letters Z,P,D,F with the right index finger. Twenty-seven neck pain participants received spinal manipulation (14 participants, 18-27 years) or sham control (13 participants, 19-24 years). Twelve healthy controls (20-27 years) also participated. Participan...Continue Reading

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Citations

Aug 28, 2020·Expert Review of Medical Devices·Kevin Pacheco-BarriosFelipe Fregni
Aug 28, 2020·Journal of Neural Transmission·Michele TinazziGiovanni Defazio
Oct 22, 2019·Chiropractic & Manual Therapies·Anne-Laure MeyerCharlotte Leboeuf-Yde
Jan 21, 2021·Brain Sciences·Lucien RobinaultHeidi Haavik
Dec 5, 2020·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Wei LiTong Yu

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