PMID: 2484607Jul 1, 1989Paper

Subclinical response to cadmium in liver cells

Biological Trace Element Research
L Müller, N H Stacey

Abstract

Effects of cadmium (Cd) in vivo and in vitro were studied in the absence of enhanced metallothionein (MT) production and overt Cd toxicity. Such a condition was established by extended oral exposure of male rats to 0.2 mumols Cd/kg and by incubation of isolated hepatocytes with up to 25 microM for 30 min. Subsequently, mitochondrial and extramitochondrial responses to Cd were recorded. Cadmium diminished the activity of cytochrome c oxidase (CYT C OX) by 50% in vivo and by 35% in vitro. In hepatocytes, this was accompanied by increased Cd and decreased protoheme (PrH) in mitochondria. Extramitochondrial PrH and cytochrome P 450 were not significantly altered. In hepatocytes from phenobarbitone pretreated rats, 25 microM Cd decreased CYT C OX but not mitochondrial PrH. Moreover, stimultaneous incubation of hepatocytes with 25 microM Cd and either 2.5 mM dithiothreitol or 5 mM reduced glutathione diminished cellular and mitochondrial Cd and prevented the decrease in CYT C OX but not that in PrH. In contrast, coincubation with either 250 microM L-buthionine-sulfoximine or diethylmaleate, which did not alter Cd uptake, prevented the decrease in PrH but not that in CYT C OX owing to Cd. These results show that Cd exerts mitochondria...Continue Reading

References

Dec 1, 1987·Toxicology and Industrial Health·C A Tyson
Feb 1, 1988·Bulletin of Environmental Contamination and Toxicology·L MullerN H Stacey
Mar 1, 1988·Archives of Environmental Contamination and Toxicology·L MullerN H Stacey
Feb 1, 1986·Toxicology and Applied Pharmacology·N H Stacey
Aug 11, 1970·Biochemical and Biophysical Research Communications·E HasegawaT R Tephly
Jun 1, 1984·Toxicology·L Müller, F K Ohnesorge
Apr 29, 1983·Science·A Meister
May 1, 1983·Archives of Environmental Contamination and Toxicology·P V Prasada RaoA B Desalu

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Citations

Jun 15, 2007·Pathophysiology of Haemostasis and Thrombosis·Mehtap Koçak, Ethem Akçil
Jan 6, 2021·Biological Trace Element Research·Viviane Gorete Silveira MouroSérgio Luis Pinto da Matta

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