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SubClonal Hierarchy Inference from Somatic Mutations: automatic reconstruction of cancer evolutionary trees from multi-region next generation sequencing

bioRxiv

Nov 26, 2014

Noushin NiknafsRachel Karchin

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Abstract

Recent improvements in deep next-generation sequencing of tumor samples and the ability to identify somatic mutations at low allelic fractions have opened the way for new approaches to model the evolution of individual cancers. The power and utility of these models is increased when tum...read more

Mentioned in this Paper

Tumor Cells, Malignant
Chronic Lymphocytic Leukemia
Simulation
Small Cell Carcinoma of Lung
Mutation Abnormality
Sodium Channel Protein Type 1 Subunit Alpha
Leukemia, Myelocytic, Acute
Genetic Programming
Recurrent Tumor
Site
15
16
Paper Details
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  • SubClonal Hierarchy Inference from Somatic Mutations: automatic reconstruction of cancer evolutionary trees from multi-region next generation sequencing

    bioRxiv

    Nov 26, 2014

    Noushin NiknafsRachel Karchin

    PMID: 990011833

    DOI: 10.1101/011833

    Abstract

    Recent improvements in deep next-generation sequencing of tumor samples and the ability to identify somatic mutations at low allelic fractions have opened the way for new approaches to model the evolution of individual cancers. The power and utility of these models is increased when tum...read more

    Mentioned in this Paper

    Tumor Cells, Malignant
    Chronic Lymphocytic Leukemia
    Simulation
    Small Cell Carcinoma of Lung
    Mutation Abnormality
    15
    16
    Paper Details
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