Subcortical Local Functional Hyperconnectivity in Cannabis Dependence

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging
Peter ManzaNora D Volkow

Abstract

Cannabis abuse (CA) has been associated with psychopathology, including negative emotionality and higher risk of psychosis, particularly with early age of initiation. However, the mechanisms underlying this association are poorly understood. Because aberrant dopamine signaling is implicated in cannabis-associated psychopathology, we hypothesized that regular CA would be associated with altered resting-state functional connectivity in dopamine midbrain-striatal circuits. We examined resting-state brain activity of subcortical regions in 441 young adults from the Human Connectome Project, including 30 subjects with CA meeting DSM-IV criteria for dependence and 30 control subjects matched on age, sex, education, body mass index, anxiety, depression, and alcohol and tobacco usage. Across all subjects, local functional connectivity density hubs in subcortical regions were most prominent in ventral striatum, hippocampus, amygdala, dorsal midbrain, and posterior-ventral brainstem. As hypothesized, subjects with CA showed markedly increased local functional connectivity density relative to control subjects, not only in ventral striatum (where nucleus accumbens is located) and midbrain (where substantia nigra and ventral tegmental nucle...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HerkenhamK C Rice
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Aug 16, 2002·American Journal of Epidemiology·J van OsH Verdoux
Nov 26, 2002·BMJ : British Medical Journal·Louise ArseneaultTerrie E Moffitt
May 21, 2003·Journal of Personality Disorders·Robert F Krueger, Jennifer L Tackett
Mar 4, 2008·Sleep Medicine Reviews·Thomas SchierenbeckMagdolna Hornyak
Aug 1, 2008·Schizophrenia Bulletin·William P HoranMichael F Green
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Francesca M FilbeyKent E Hutchison
Sep 10, 2009·JAMA : the Journal of the American Medical Association·Nora D VolkowJames M Swanson
Jan 12, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hendrika H van HellNick F Ramsey
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dardo Tomasi, Nora D Volkow
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Jul 14, 2010·Progress in Neurobiology·Matthijs G Bossong, Raymond J M Niesink
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nora D VolkowFrank Telang
May 26, 2011·NeuroImage·Dardo Tomasi, Nora D Volkow
Jul 6, 2011·Molecular Psychiatry·D Tomasi, N D Volkow
Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Dec 14, 2011·Biological Psychiatry·Dardo Tomasi, Nora D Volkow
Mar 1, 2012·NeuroImage·D C Van EssenUNKNOWN WU-Minn HCP Consortium
May 31, 2012·Cerebral Cortex·David M ColeChristian F Beckmann
Jun 26, 2012·Schizophrenia Research·Juan A Galvez-BuccolliniLynn E Delisi
Aug 8, 2012·Molecular Psychiatry·J L ThompsonA Abi-Dargham
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Madeline H MeierTerrie E Moffitt
Mar 6, 2013·Neuroscience and Biobehavioral Reviews·Zoran VukadinovicIvana Rosenzweig
Jul 4, 2013·Biological Psychiatry·Michael A P BloomfieldOliver D Howes
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dardo TomasiNora D Volkow
Jan 15, 2014·Journal of Psychiatric Research·Jesus PujolRocío Martín-Santos
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Nora D VolkowDardo Tomasi
Jul 25, 2014·Brain : a Journal of Neurology·Nicolas A CrossleyEdward T Bullmore
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Francesca M FilbeyJudith Segall
Jan 30, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Barbara J WeilandKent E Hutchison
Feb 28, 2015·Brain Research·Anna B KonovaRita Z Goldstein
Apr 2, 2015·Schizophrenia Bulletin·Marco ColizziMarta Di Forti
Jan 5, 2016·Journal of Addictive Diseases·Deirdre A ConroyMichael D Stein

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Citations

May 4, 2018·The American Journal of Drug and Alcohol Abuse·Namkee G ChoiC Nathan Marti
Nov 7, 2019·Molecular Psychiatry·Peter ManzaNora D Volkow
Feb 6, 2020·Focus : Journal of Life Long Learning in Psychiatry·Amna ZehraGene-Jack Wang
Feb 26, 2020·Science Advances·Caitlin E BurgdorfAnjali M Rajadhyaksha
Dec 7, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Şükrü Barış DemiralNora D Volkow
May 24, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sheri L ToweLinda Chang
Mar 21, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Amna ZehraGene-Jack Wang
Apr 8, 2020·Frontiers in Psychiatry·Adellah SariahXiaojun Huang
Jun 1, 2021·Frontiers in Psychiatry·Katherine L McPhersonNora D Volkow

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