Subcortical nuclei in Alzheimer's disease: a volumetric and diffusion kurtosis imaging study

Acta Radiologica
Ming-Liang WangWen-Bin Li

Abstract

Background Previous studies revealed that subcortical nuclei were harmed in the process of Alzheimer's disease (AD). Purpose To investigate the volumetric and diffusion kurtosis imaging (DKI) parameter changes of subcortical nuclei in AD and their relationship with cognitive function. Materials and Methods A total of 17 mild AD patients, 15 moderate to severe AD patients, and 16 controls underwent neuropsychological tests and magnetic resonance imaging (MRI) scans. Volume, mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA) were measured in hippocampus, thalamus, caudate, putamen, pallidum, and amygdala. MRI parameters were compared. Correlation analysis was performed between subcortical nuclei volume, DKI parameters, and MMSE score. Results Significant volume reduction was seen in the left hippocampus in mild AD, and the bilateral hippocampus, thalamus, putamen, left caudate, and right amygdala in moderate to severe AD ( P < 0.05). Increased MD values were observed in the left hippocampus, left amygdala, and right caudate in mild AD, and the bilateral hippocampus and right amygdala in moderate to severe AD ( P < 0.05). Decreased MK values were observed only in the bilateral hippocampus in moderate to seve...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Jun 8, 2002·Annual Review of Neuroscience·Mark G Packard, Barbara J Knowlton
May 5, 2004·Neurobiology of Aging·Corina PennanenHilkka Soininen
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Nov 22, 2008·Brain : a Journal of Neurology·L W de JongJ van der Grond
Mar 24, 2010·Journal of Alzheimer's Disease : JAD·Andrea CherubiniGianfranco Spalletta
Jan 18, 2011·Journal of Neurology·Jee Hoon RohDuk L Na
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ali TabeshJoseph A Helpern
Mar 1, 2011·NeuroImage·Brian PatenaudeMark Jenkinson
Mar 16, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Greetje VanhoutteAnnemie Van der Linden
Oct 8, 2015·Journal of Alzheimer's Disease : JAD·Hanne StruyfsSebastiaan Engelborghs
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Pierre EustachePatrice Péran
Nov 16, 2016·Journal of Inflammation Research·Maria Rosanna BronzuoliCaterina Scuderi
Nov 17, 2016·Brain Research·Vasileios Tentolouris-PiperasKirsi M Kinnunen

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Software Mentioned

Diffusion Kurtosis Estimator DKE
FIRST toolbox
FMRIB
eddy
Statistical Package for Social Sciences (
FSL
SNAP
Flirt
FIRST
ITK

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