Subcortical nuclei volumes in suicidal behavior: nucleus accumbens may modulate the lethality of acts

Brain Imaging and Behavior
Anthony J GifuniF Jollant

Abstract

Previously, studies have demonstrated cortical impairments in those who complete or attempt suicide. Subcortical nuclei have less often been implicated in the suicidal vulnerability. In the present study, we investigated, with a specific design in a large population, variations in the volume of subcortical structures in patients with mood disorders who have attempted suicide. We recruited 253 participants: 73 suicide attempters with a past history of both mood disorders and suicidal act, 89 patient controls with a past history of mood disorders but no history of suicidal act, and 91 healthy controls. We collected 1.5 T magnetic resonance imaging data from the caudate, pallidum, putamen, nucleus accumbens, hippocampus, amygdala, ventral diencephalon, and thalamus. Surface-based morphometry (Freesurfer) analysis was used to comprehensively evaluate gray matter volumes. In comparison to controls, suicide attempters showed no difference in subcortical volumes when controlled for intracranial volume. However, within attempters negative correlations between the left (r = -0.35, p = 0.002), and right (r = -0.41, p < 0.0005) nucleus accumbens volumes and the lethality of the last suicidal act were found. Our study found no differences ...Continue Reading

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Citations

Nov 18, 2015·Brain Imaging and Behavior·András KirályZsigmond Tamás Kincses
Sep 30, 2016·Psychiatry Research. Neuroimaging·Savannah N GosnellRamiro Salas
Sep 27, 2018·Social Cognitive and Affective Neuroscience·Tiffany C HoIan H Gotlib
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Dec 4, 2019·The European Journal of Neuroscience·Aiste LengvenyteEmilie Olié
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Apr 7, 2021·Biological Psychiatry·Jennifer BarredoNoah S Philip
Nov 3, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bronwyn J OversJanice M Fullerton

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