Subcortical origin of visuomotor apraxia

Brain : a Journal of Neurology
J ClassenH J Freund

Abstract

Visuomotor apraxia (VMA) is a clinical syndrome characterized by a failure to make use of visual information when performing a target-directed movement. Visuomotor apraxia has traditionally been assumed to result from a disconnection of cortico-cortical fibres between visual and motor areas following occipito-parietal lesions. We describe a patient who developed a permanent contralesional and a temporary ipsilesional visuomotor apraxia as part of a complex neurological syndrome after a right [corrected] thalamic haemorrhage. MRI showed that the suprathalamic white matter was not involved but the most caudal fibres of the internal capsule appeared to be interrupted. To our knowledge this is the first case of a VMA with a lesion restricted to a deep subcortical area indicating that VMA can result from damage to subcortical projections rather than interruption of cortico-cortical fibres.

Citations

Aug 10, 2006·Experimental Brain Research·M WilsonD E Marple-Horvat
Feb 29, 2008·Journal of Neurology·Anna K HödlRaphael M Bonelli
Nov 13, 2008·The Cerebellum·Mitchell Glickstein, Karl Doron
Sep 15, 2010·The Cerebellum·Nadia L Cerminara, Richard Apps
Jan 21, 2006·The Journal of Physiology·Omür Budanur MilesDilwyn E Marple-Horvat
Sep 27, 2003·The European Journal of Neuroscience·Antonia L EdgeRichard Apps
Jun 17, 2010·The European Journal of Neuroscience·Roberto CaminitiApostolos P Georgopoulos
Dec 14, 2004·NeuroImage·Christian GrefkesGereon R Fink
Feb 15, 2002·Brain : a Journal of Neurology·Alexandra Battaglia-Mayer, Roberto Caminiti

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