Subcortical vascular cognitive impairment: similarities and differences with multiple sclerosis

Journal of the Neurological Sciences
Reinhold SchmidtFranz Fazekas

Abstract

Subcortical vascular cognitive impairment is caused by lacunes and widespread ischemic white matter damage which closely resembles white matter abnormalities seen in multiple sclerosis. Recent evidence suggests that the progression rate of ischemic white matter lesions on MRI is very similar to that observed in multiple sclerosis. Consequently, it has been proposed to use MRI for monitoring disease activity not only in multiple sclerosis but also in vascular dementia trials. There is first evidence from magnetization transfer imaging studies that other than in MS normal appearing white matter is not affected in cerebral small vessel disease. This contrasts the hypothesis that ischemic white matter damage extends far beyond changes visible on conventional MR. The cognitive consequences of both diseases are strikingly similar which is at least partly caused by damage to frontal-subcortical circuits. Involvement of these common functional anatomical structures and their modulatory transmitter systems has now led to common interventional approaches such as the use of cholinesterase inhibitors.

References

Jul 1, 1995·Stroke; a Journal of Cerebral Circulation·L Pantoni, J H Garcia
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·A F LeuchterT F Newton
Jan 5, 1999·Brain : a Journal of Neurology·N R SeldenM M Mesulam
Aug 26, 1999·Neuroepidemiology·K RockwoodS Darvesh
Sep 4, 1999·Journal of the Neurological Sciences·H HanyuK Abe
Oct 12, 1999·Multiple Sclerosis : Clinical and Laboratory Research·A FeinsteinK Feinstein
Dec 28, 1999·Alzheimer Disease and Associated Disorders·G C Román, D R Royall
Jan 22, 2000·Radiology·J W BurrussL A Hayman
Aug 10, 2002·Journal of Psychosomatic Research·Sibel Tekin, Jeffrey L Cummings
Oct 17, 2002·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Massimo FilippiMarco Rovaris
Jun 20, 2003·Lancet·Reinhold SchmidtUNKNOWN Austrian Stroke Prevention Study
Aug 27, 2003·Neurology·D WilkinsonUNKNOWN Donepezil 308 Study Group
Sep 13, 2003·Stroke; a Journal of Cerebral Circulation·Sandra BlackUNKNOWN Donepezil 307 Vascular Dementia Study Group
Sep 7, 2004·Annals of Neurology·Klaus SchmiererDavid H Miller
May 17, 2005·Journal of the Neurological Sciences·Alexandra Kutzelnigg, Hans Lassmann
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Christian BoctiSandra E Black
Sep 30, 2005·International Psychogeriatrics·John Bowler

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Citations

Feb 23, 2011·Journal of Neural Transmission·Reinhold SchmidtFranz Fazekas
Jun 13, 2012·Journal of the International Neuropsychological Society : JINS·Juan José Soriano-RayaMaria Mataró
Jun 21, 2011·Lancet Neurology·Miguel D'haeseleerJacques De Keyser
Apr 20, 2010·Clinical Neurology and Neurosurgery·Margit JehnaChristian Enzinger
Aug 16, 2012·Journal of Neuropathology and Experimental Neurology·G R Wayne Moore, Cornelia Laule
Jun 25, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miguel D'haeseleerMarie B D'hooghe
Jul 3, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jacques De KeyserMarcus W Koch
May 31, 2016·Multiple Sclerosis and Related Disorders·Philipp EiseleAchim Gass
Nov 19, 2013·Neurobiology of Aging·Marina Fernández-AndújarMaria Mataró
Dec 19, 2014·Brain Pathology·Gabriele C DeLucaSarah A Morrow
Mar 10, 2018·Nature Reviews. Neurology·Ruth GeraldesUNKNOWN MAGNIMS study group
Jun 13, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Zafer KeserKhader M Hasan
Oct 26, 2012·Journal of the International Neuropsychological Society : JINS·Sarah E CookMichael Crowe
Apr 12, 2007·Expert Opinion on Pharmacotherapy·Mario ScartozziStefano Cascinu
Apr 24, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mariana BrancoMaria Pia Amato

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