Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism

Adipocyte
A D BoothM T Foster

Abstract

The protective effects of lower body subcutaneous adiposity are linked to the depot functioning as a "metabolic sink" receiving and sequestering excess lipid. This postulate, however, is based on indirect evidence. Mechanisms that mediate this protection are unknown. Here we directly examined this with progressive subcutaneous adipose tissue removal. Ad libitum chow fed mice underwent sham surgery, unilateral or bilateral removal of inguinal adipose tissue or bilateral removal of both inguinal and dorsal adipose tissue. Subsequently mice were separated into 5 week chow or 5 or 13 week HFD groups (N = 10 per group). Primary outcome measures included adipocyte distribution, muscle and liver triglycerides, glucose tolerance, circulating adipocytokines and muscle insulin sensitivity. Subcutaneous adipose tissue removal caused lipid accumulation in femoral muscle proximal to excision, however, lipid accumulation was not proportionally inverse to adipose tissue quantity excised. Accumulative adipose removal was associated with an incremental reduction in systemic glucose tolerance in 13 week HFD mice. Although insulin-stimulated pAkt/Akt did not progressively decrease among surgery groups following 13 weeks of HFD, there was a suppre...Continue Reading

References

Dec 1, 1991·Diabetes Care·P Björntorp
Mar 1, 1994·The American Journal of Physiology·A M SherryD H Malinowska
Oct 1, 1994·Physiological Reviews·A H Kissebah, G R Krakower
Jan 1, 1997·The American Journal of Physiology·C Boudreau-LarivièreB J Jasmin
Sep 26, 1997·The Journal of Clinical Investigation·E FerranniniG Mingrone
Oct 23, 1997·Physiology & Behavior·M M Mauer, T J Bartness
Apr 15, 2000·Nature·P G Kopelman
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R V WeberJ G Kral
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·M M MauerT J Bartness
Feb 28, 2001·Obesity Research·C D BrownM Horan
Dec 6, 2001·Metabolism: Clinical and Experimental·E A Sims
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Yolanta T KruszynskaJerrold M Olefsky
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Kirsi A VirtanenPirjo Nuutila
Aug 29, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M González-OrtizE Martínez-Abundis
Sep 21, 2002·Diabetologia·K N Frayn
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F M FisherS Kumar
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason M MontezJeffrey M Friedman
Nov 16, 2005·Atherosclerosis·Demosthenes B PanagiotakosChristodoulos Stefanadis
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Luc BertrandJean-Louis Vanoverschelde
May 31, 2006·Aesthetic Plastic Surgery·Yoon Gi HongWon Young Lee
Jul 30, 2009·American Journal of Physiology. Endocrinology and Metabolism·Hui-Yu LiuWenhong Cao
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
Jan 13, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K N ManolopoulosK N Frayn
Sep 17, 2011·Journal of the American College of Cardiology·Christina VoulgariChristodoulos Stefanadis

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Citations

Jul 5, 2019·Journal of Gastroenterology and Hepatology·Goh Eun ChungAijaz Ahmed
May 16, 2019·Journal of Leukocyte Biology·Lauar MonteiroPedro Manoel M Moraes-Vieira
Dec 24, 2018·Frontiers in Endocrinology·Natasha Morales DrissiMaria Engström
Aug 31, 2021·American Journal of Physiology. Endocrinology and Metabolism·Anna MikolajczakJennifer A Thompson
Oct 12, 2021·Experimental and Therapeutic Medicine·Ioana BinișorCătălina Gabriela Pisoschi

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