Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia

Vascular Health and Risk Management
Adriana Aparecida Siviero-MiachonGil Guerra-Junior

Abstract

The aim of this study was to evaluate the relationship between body composition, metabolic profile, adipokines, and carotid intima-media thickness (cIMT) in young survivors of childhood acute lymphocytic leukemia (ALL). This cross-sectional study compared 55 ALL survivors, of chronological age between 15 years and 24 years, assigned into two groups according to the exposure to cranial radiation therapy (CRT; 25 irradiated and 30 nonirradiated) with 24 leukemia-free controls, and assessed body fat mass (dual-energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, blood pressure (BP), adipokines, and cIMT by a multiple regression analysis. Treatment with CRT had an effect on all of the variables derived from the computed tomography scan: visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (P<0.050). In a multiple linear regression model, cIMT positively correlated with exposure to CRT (P=0.029), diastolic BP (P=0.016), and leptin-to-adiponectin ratio (P=0.048), while negatively related to SAT (P=0.007). In young survivors of childhood ALL, CRT modified the distribution of fat and played a critical role in determining cIMT. Leptin-to-adiponectin ratio, a biomarker of ...Continue Reading

Citations

Mar 10, 2016·Current Treatment Options in Oncology·Todd M GibsonKirsten K Ness
Dec 15, 2015·Journal of Bone and Mineral Metabolism·Adriana Aparecida Siviero-MiachonGil Guerra-Junior
Dec 7, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marshall J GlesbyAnjali Sharma
Sep 3, 2020·Annals of Pediatric Endocrinology & Metabolism·Adriana Aparecida Siviero-MiachonGil Guerra-Junior

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Methods Mentioned

BETA
X-ray
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
R

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