Subcutaneous administration of a depot gonadotropin-releasing hormone agonist induces profound reproductive axis suppression in women

Fertility and Sterility
M FilicoriP Casadio

Abstract

To compare the i.m. and s.c. routes of depot GnRH agonist administration. Prospective, controlled pharmacokinetics study. Volunteers in an academic research environment. Forty women with benign gynecologic disorders. Triptorelin administration (3.75 mg) at 28-day intervals for 6 consecutive months. Twenty patients were treated with IM triptorelin, and 20 patients were treated with SC triptorelin. Assessment of side effects, GnRH test results, and triptorelin, LH, FSH, estradiol, and progesterone levels. The occurrence of injection site redness and itching and of some hypoestrogenic side effects was increased significantly in the SC group. Plasma triptorelin levels were significantly higher in the IM group in the first month of treatment; thereafter, the pattern reversed, with a nonsignificant trend toward higher plasma triptorelin levels in the SC group. Serum LH, FSH, estradiol, and progesterone levels were low after the first month of treatment and did not differ between the two treatment groups. On day 196 (2 months after the last depot triptorelin injection), triptorelin was still measurable and gonadotropins and gonadal steroids were still suppressed. Spontaneous menses returned significantly later in the SC group than in ...Continue Reading

Citations

Jan 16, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yan LiangXiaoping Luo
Aug 6, 2000·Fertility and Sterility·T K CheungP K Lam
Feb 27, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Yan LiangXiaoping Luo
Dec 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lutz R AsmusMichael Möller
Jul 1, 2020·Expert Opinion on Drug Metabolism & Toxicology·Luigi Della CortePierluigi Giampaolino
Oct 7, 2008·Animal Reproduction Science·Atunga NyachieoThomas M D'Hooghe

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