Subcutaneous and total fat at L4-L5 and subcutaneous, visceral and total fat at L3-L4 are important contributors of fasting and postprandial adiponectin levels

Endocrine Research
Simoni A KatergariDimitrios N Papachristou

Abstract

Insulin resistance and central obesity have been implicated in the pathogenesis of hypoadiponectinemia in obesity. The aim of this study is to evaluate circulating post-prandial adiponectin in relation to glucose and insulin metabolism, indexes of insulin resistance and sensitivity and, indexes of body fat accumulation and distribution in obese men. Twenty-eight non-diabetic men underwent an OGTT followed by an oral fat load and were studied at baseline and for 5 h post-prandially for serum adiponectin, glucose and insulin. Insulin resistance was estimated by Homeostasis model assessment (HOMA) and insulin sensitivity by Matsuda index. Body fat accumulation and distribution were evaluated by anthropometric indexes and multiple slices MRI of the abdomen and hip. Adiponectin was negatively correlated to insulin levels. Fasting and area under the curve (AUC) adiponectin levels were negatively correlated to HOMA (both p < 0.01) and positively to Matsuda index (both p < 0.05). Negative correlations between fasting adiponectin and total fat (r = -0.408, p < 0.05), AUC adiponectin and subcutaneous, visceral and total fat (r = -0.375, -0.413 and -0.475 respectively, all p < 0.05) at L3-L4 were found, and negative correlations between f...Continue Reading

References

Jun 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·S N Meydani
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·A N PeirisA H Kissebah
Jul 1, 1995·The Journal of Clinical Investigation·N AbateS M Grundy
Feb 1, 1995·Diabetes Care·D B AllisonF X Pi-Sunyer
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Jul 27, 2001·International Journal of Experimental Diabetes Research·M A StatnickJ F Caro
May 29, 2002·The Journal of Biological Chemistry·Naoto KubotaTetsuo Noda
Jul 2, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P W PeakeJ A Charlesworth
Jan 24, 2004·Diabetes Research and Clinical Practice·Keun-Gyu ParkIn-Kyu Lee
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Johan HoffstedtPeter Arner
May 20, 2004·Molecular and Cellular Endocrinology·Aina S LihnBjørn Richelsen
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bulent O YildizJulio Licinio
Oct 6, 2005·The Journal of Clinical Endocrinology and Metabolism·K StaigerH-U Häring
Jun 21, 2007·American Journal of Physiology. Endocrinology and Metabolism·E MauryS M Brichard
Feb 7, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J HungJ P Beilby
Sep 17, 2009·The Journal of Clinical Endocrinology and Metabolism·L FrederiksenM Andersen

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Jul 28, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W MaL Qi

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