Subcutaneous delivery of tauroursodeoxycholic acid rescues the cone photoreceptors in degenerative retina: A promising therapeutic molecule for retinopathy

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ye TaoJianbin Zhang

Abstract

Inherited retinal degeneration (RD) comprises a heterogeneous group of retinopathies that rank among the main causes of blindness. Tauroursodeoxycholic acid (TUDCA) is taurine conjugate hydrophilic bile acid that demonstrates profound protective effects against a series of neurodegenerative diseases related to oxidative stress. This study sought to evaluate the TUDCA induced effects of on a pharmacologically induced RD animal model by electroretinogram (ERG) examination, behavior tests, morphological analysis and immunochemistry assay. Massive photoreceptor degeneration in mice retina was induced by an intraperitoneal administration of N-methyl-N-nitrosourea(MNU). Subcutaneous delivery of TUDCA inhibits effectively the photoreceptor loss and visual impairments in the MNU administered mice. In the retinal flat-mounts of TUDCA treated mice, the cone photoreceptors were efficiently preserved. Furthermore, the multi-electrodes array (MEA) was used to detect the firing activities of retinal ganglion cells within the inner retinal circuits. TUDCA therapy could restrain the spontaneous firing response, enhance the light induced firing response, and preserve the basic configurations of ON-OFF signal pathway in degenerative retinas. Our...Continue Reading

References

Apr 1, 1996·Digestive Diseases and Sciences·A CrosignaniM Podda
Feb 13, 1999·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C FriedburgE Zrenner
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing XieBoris Yoffe
May 27, 2004·Investigative Ophthalmology & Visual Science·Dao-Yi YuJonathan Stone
Jul 16, 2004·American Journal of Physiology. Cell Physiology·Tomoka TakataniJunichi Azuma
May 11, 2005·Neuron·Jason L PuchallaMichael J Berry
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Francesca DoonanThomas G Cotter
Jul 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Keiichi KomeimaPeter A Campochiaro
Aug 1, 2006·Investigative Ophthalmology & Visual Science·Mingliang PuHong Zhang
Jun 27, 2007·Investigative Ophthalmology & Visual Science·Robert E MarcRobert J Lucas
Oct 5, 2007·Eye·R E MacLaren, R A Pearson
Apr 26, 2008·Investigative Ophthalmology & Visual Science·M Joe PhillipsMachelle T Pardue
Aug 1, 2008·Journal of Neurophysiology·Hain-Ann HsuehFrank S Werblin
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lisiane B MeiraLeona D Samson
May 7, 2009·Journal of Lipid Research·Joana D AmaralCecília M P Rodrigues
Jun 9, 2009·Progress in Retinal and Eye Research·Debarshi MustafiKrzysztof Palczewski
Jan 5, 2010·Journal of Ocular Biology, Diseases, and Informatics·Jeffrey H BoatrightMachelle T Pardue
Mar 11, 2011·Journal of Neurophysiology·Chris SekirnjakE J Chichilnisky
Apr 22, 2011·Investigative Ophthalmology & Visual Science·Laura Fernández-SánchezNicolás Cuenca
Mar 1, 2012·Journal of Pharmacological Sciences·Kazuhiro TsurumaHideaki Hara
Apr 21, 2012·Current Molecular Medicine·D TrifunovićF Paquet-Durand
Apr 26, 2012·Investigative Ophthalmology & Visual Science·Tao ZhangYingbin Fu
May 4, 2012·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Laura ObiciGiampaolo Merlini
Feb 11, 2014·Experimental Eye Research·Yuan-Yuan ChenYin Shen
Mar 26, 2014·Advances in Experimental Medicine and Biology·Marijana Samardzija, Christian Grimm
May 24, 2014·Investigative Ophthalmology & Visual Science·Hidetaka MatsumotoDemetrios G Vavvas
Jun 4, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Sheila VangWalter C Low
Aug 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura Fernández-SánchezNicolás Cuenca
Oct 3, 2015·Advances in Experimental Medicine and Biology·Eric C LawsonMachelle T Pardue
Jan 19, 2016·Investigative Ophthalmology & Visual Science·Coralie GianesiniGianluca Tosini
Apr 28, 2016·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·M Dominik Fischer
Jun 29, 2016·Acta Ophthalmologica·Daniel S NarayanRobert J Casson
Aug 21, 2016·Cellular and Molecular Life Sciences : CMLS·Thierry Léveillard, José-Alain Sahel

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Stephanie M Grant, Sharon DeMorrow
Mar 7, 2021·Biomolecules·Alice WinMenaka C Thounaojam
Mar 7, 2021·International Journal of Molecular Sciences·Lorena Olivares-GonzálezRegina Rodrigo
Jul 9, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Pijun YanRan Liu

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