Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans

The Journal of Clinical Endocrinology and Metabolism
Diana L AlbaSuneil K Koliwad

Abstract

Type 2 diabetes presents at a lower body mass index (BMI) in Chinese individuals than in white individuals. We sought to determine the role of subcutaneous adipose tissue (SCAT)-intrinsic factors, vs BMI or adiposity per se, in the vulnerability of Chinese individuals to obesity-associated impairment of insulin sensitivity. Thirty-two Chinese and 30 white men and women from a cohort in the San Francisco Bay Area underwent anthropometric measurements, body composition (dual-energy X-ray absorptiometry) analyses, and measurement of fasting plasma glucose and insulin. Forty-eight also provided abdominal SCAT samples for transcriptional and biochemical analyses of tissue fibrosis. BMI correlated with total body fat in white (r = 0.74, P < 0.001) but not Chinese individuals, whereas BMI correlated with visceral adipose tissue (VAT) accrual in both ethnicities (r = 0.88 and 0.81, respectively; P < 0.01). Insulin resistance (homeostatic model assessment of insulin resistance) worsened with VAT mass, but not total body fat, in Chinese subjects (r = 0.63, P < 0.01), whereas it worsened with both in white individuals. By contrast, SCAT mRNA levels of genes encoding profibrotic proteins rose remarkably along with both BMI and VAT mass in ...Continue Reading

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Citations

Oct 5, 2019·International Journal of Molecular Sciences·Francisco Javier Ruiz-OjedaJulio Plaza-Díaz
Jun 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Mariam HaffaDominique Scherer
Aug 23, 2020·International Journal of Molecular Sciences·Megan K DeBari, Rosalyn D Abbott
Mar 9, 2021·Frontiers in Nutrition·Alistaire D RuggieroKylie Kavanagh
Jun 10, 2021·Reviews in Endocrine & Metabolic Disorders·Geneviève Marcelin, Karine Clément
Jul 1, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xin SuBin Wang

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