Subcutaneous fat mass in infancy and cardiovascular risk factors at school-age: The generation R study

Obesity
Susana SantosV W V Jaddoe

Abstract

To examine the associations of infant subcutaneous fat with cardiovascular risk factors at school-age. In a population-based prospective cohort study among 808 children, total subcutaneous fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central-to-total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thicknesses/total subcutaneous fat) at 1.5 and 24 months were estimated. At 6 years, body mass index, blood pressure, cholesterol, triglycerides, and insulin levels were measured. Infant subcutaneous fat measures were not associated with childhood blood pressure, triglycerides, or insulin levels. A 1-standard-deviation score (SDS) higher total subcutaneous fat at 1.5 months was, independently of body mass index, associated with lower low-density lipoprotein (LDL)-cholesterol levels at 6 years. In contrast, a 1-SDS higher total subcutaneous fat at 24 months was associated with higher total-cholesterol [difference 0.13 (95% confidence interval (CI) 0.03, 0.23) SDS] and LDL-cholesterol levels [difference 0.12 (95% CI 0.02, 0.21) SDS] at 6 years. There were no associations of central-to-total subcutaneous fat ratio with childhood cholesterol levels. These results suggest that in...Continue Reading

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Citations

Feb 22, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N PatelL Poston
Jul 3, 2018·Maternal & Child Nutrition·Kathryn V DalrympleMajella O'Keeffe
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May 21, 2021·International Breastfeeding Journal·Sisitha JayasingheAndrew P Hills
Jun 7, 2021·Environmental Health : a Global Access Science Source·William B PattersonTanya L Alderete

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