Subcutaneous immunotherapy with purified Der p1 and 2 suppresses type 2 immunity in a murine asthma model

Allergy
Laura HesseMartijn C Nawijn

Abstract

Allergen-specific immunotherapy can induce long-term suppression of allergic symptoms, reduce medication use, and prevent exacerbations of allergic rhinitis and asthma. Current treatment is based on crude allergen extracts, which contain immunostimulatory components such as β-glucans, chitins, and endotoxin. Use of purified or recombinant allergens might therefore increase efficacy of treatment. Here, we test application of purified natural group 1 and 2 allergens from Dermatophagoides pteronyssinus (Der p) for subcutaneous immunotherapy (SCIT) treatment in a house dust mite (HDM)-driven mouse model of allergic asthma. HDM-sensitized mice received SCIT with crude HDM extract, a mixture of purified Der p1 and 2 (DerP1/2), or placebo. Upon challenges, we measured specific immunoglobulin responses, allergen-induced ear swelling response (ESR), airway hyperresponsiveness (AHR), and inflammation in bronchoalveolar lavage fluid (BAL) and lung tissue. ESR measurement shows suppression of early allergic response in HDM-SCIT- and DerP1/2-SCIT-treated mice. Both HDM-SCIT and DerP1/2-SCIT are able to suppress AHR and eosinophilic inflammation. In contrast, only DerP1/2-SCIT is able to significantly suppress type 2 cytokines in lung tissue...Continue Reading

References

Jan 1, 1986·International Archives of Allergy and Applied Immunology·H YasuedaT Shida
Jul 3, 1998·The Journal of Clinical Investigation·C A AkdisK Blaser
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M J Van Der VeenJ S van der Zee
Apr 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G PittnerR Valenta
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Thomas M KündigMartin F Bachmann
Oct 6, 2006·The New England Journal of Medicine·Peter S CreticosUNKNOWN Immune Tolerance Network Group
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A AsturiasA Martínez
Mar 3, 2010·Annual Review of Immunology·Rudolf ValentaSusanne Vrtala
Aug 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soheila ShirinbakMartijn C Nawijn
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Cezmi A Akdis, Mübeccel Akdis
Apr 16, 2011·The Journal of Allergy and Clinical Immunology·Adnan CustovicPatrick G Holt
Nov 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S TourdotP Moingeon
Jul 14, 2012·The Journal of Allergy and Clinical Immunology·Kuan-Wei ChenSusanne Vrtala
Nov 28, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Tomokazu MatsuokaStephen R Durham
Jan 7, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Piotr S KowalskiJan A A M Kamps
May 27, 2014·Current Treatment Options in Allergy·Katharina MarthVerena Niederberger
Nov 13, 2014·Molecular & Cellular Proteomics : MCP·Adnan HalimHans H Wandall
Mar 27, 2015·Science Translational Medicine·Cezmi A Akdis, Mübeccel Akdis
Jul 23, 2015·Immunity·Hamida Hammad, Bart N Lambrecht
Oct 29, 2015·Current Opinion in Allergy and Clinical Immunology·Erik Wambre
Dec 15, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D HinzA Sette
Oct 30, 2016·The Journal of Allergy and Clinical Immunology·Daniela PosaPaolo Maria Matricardi
Jan 8, 2017·Methods in Molecular Biology·Laura Hesse, Martijn C Nawijn
Jan 26, 2017·Allergy·H J HoffmannP Sørensen

❮ Previous
Next ❯

Citations

Aug 8, 2018·Expert Review of Respiratory Medicine·Cevdet OzdemirCezmi A Akdis
May 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie LiRongfei Zhu
Aug 14, 2019·Current Opinion in Allergy and Clinical Immunology·Pattraporn SatitsuksanoaMübeccel Akdis
Jun 20, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Kyung Hee ParkJung-Won Park
Sep 10, 2020·Allergy·Yifan MengLuo Zhang
Aug 18, 2020·Molecular Biology Reports·Hui Cao, Zhigang Liu
Oct 7, 2018·Current Allergy and Asthma Reports·Rodrigo Jiménez-Saiz, Sarita U Patil
Oct 1, 2020·Allergy·Lacin CevhertasCezmi A Akdis
Oct 2, 2020·Current Opinion in Allergy and Clinical Immunology·Zeynep Celebi SözenerCezmi Akdis
Dec 15, 2020·Current Allergy and Asthma Reports·Gabija DrazdauskaitėMohamed H Shamji
Sep 10, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Umut C KucuksezerCezmi A Akdis

❮ Previous
Next ❯

Methods Mentioned

BETA
size exclusion chromatography
electrophoresis
bronchoalveolar
lavage
ELISA
bronchoalveolar lavage
ESR

Software Mentioned

SPSS
Citeq
FlexiVent

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.