PMID: 7543971Feb 1, 1995Paper

Subcutaneous implanted chambers in different mouse strains as an animal model to study genetic stability during infection with Lyme disease Borrelia

Microbial Pathogenesis
M JonssonS Bergström

Abstract

Tissue metal net cages were implanted subcutaneously in BALB/cJ and C3H/Tif mice as an experimental model of Borrelia burgdorferi infection. B. burgdorferi sensu stricto strain Sh2-82 could be isolated up to 14 weeks after the inoculation. However, a significant difference in infectivity between the two mice strains was observed. C3H/Tif mice were more susceptible to developing chronic B. burgdorferi s.s. infections than BALB/cJ mice. Although a B. burgdorferi infection was established, no rearrangements in the ospA and ospB genes were observed in any of the infected mice.

References

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Citations

May 23, 2006·Infection and Immunity·Philip E StewartPatricia A Rosa
May 23, 2003·Infection and Immunity·Chad S BrooksDarrin R Akins
May 29, 1998·The Journal of Clinical Investigation·D R AkinsJ D Radolf
Oct 11, 2003·FEMS Microbiology Reviews·Juan AnguitaErol Fikrig
Feb 3, 2005·Nature Reviews. Microbiology·Patricia A RosaPhilip E Stewart

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