Subcutaneous inflammation (panniculitis) in tibio-tarsal joint of rats inoculated with complete Freund's adjuvant

Clinical and Experimental Medicine
P G OliveiraR M Xavier

Abstract

Complete Freund's adjuvant (CFA)-induced arthritis in rats, which presents similar features to rheumatoid arthritis, is a model widely used in aetiopathogenetic and investigational drug studies. In this model, arthritis is induced by intradermal injection of Mycobacterium tuberculosis suspended in mineral oil in the hind footpad. Although the histopathology findings in the joint are well described, the marked subcutaneous features of panniculitis that concomitantly occur in this model have received no attention. The objective of this paper is to describe the subcutaneous histopathological features in 8 Wistar rats after intraplantar injection of CFA. We studied the subcutaneous histopathological features in 8 Wistar rats after intraplantar injection of CFA in the left hind paw. The levels of subcutaneous inflammation of the animals in this study were evaluated for the histological characteristics present in the tissue and scored with 4 parameters (acute inflammation, chronic inflammation with fibrosis, subcutaneous and profound soft tissue necrosis, and the presence of giant cells, neutrophils, macrophages and lymphocytes) on days 4, 7, 11 and 15 after induction. All animals developed intense subcutaneous inflammation character...Continue Reading

References

Aug 1, 1997·The American Journal of Dermatopathology·J W Schneider, H F Jordaan
Dec 21, 2000·Current Rheumatology Reports·B JoeR L Wilder
Aug 23, 2002·Current Opinion in Rheumatology·B Anne Eberhard, Norman T Ilowite
Nov 1, 2006·Arthritis and Rheumatism·Janet L FunkBarbara N Timmermann

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Citations

Apr 23, 2016·Cell Biochemistry and Function·Karine Lanes da SilveiraDaniela Bitencourt Rosa Leal
Jan 16, 2017·Toxicon : Official Journal of the International Society on Toxinology·Juan Manuel ValverdeGuillermo León
Nov 7, 2019·Journal of Cellular Biochemistry·Renata da Silva Pereira SaccolDaniela Bitencourt Rosa Leal

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