Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation

Peptides
Rumi Naono-NakayamaT Nishimori

Abstract

Endokinins, encoded by the human preprotachykinin C (PPT-C)/TAC4 gene, are peptides that consist of endokinin A (EKA), B (EKB), C (EKC) and D (EKD) and belong to the tachykinin family. Intrathecal injection of EKC/D (using the common carboxyl-terminal duodecapeptide in EKC and EKD) markedly attenuated the induction of thermal hyperalgesia and scratching behavior by intrathecal administration of substance P (SP), indicating that EKC/D has an antagonistic effect on the neurokinin 1 receptor (NK1R), SP-preferring receptor, at the spinal level; however, the pharmacological function of EKC/D at the periphery is not yet understood. Therefore, to clarify the effect of EKC/D on the peripheral tissue, the effect of subcutaneous injection of EKC/D on carrageenan-induced inflammation was examined. Subcutaneous injection of EKC/D attenuated an increase in paw volume following carrageenan-induced inflammation in a dose-dependent manner. Indeed, the increased paw volume was significantly decreased 40 min after treatment with 10(-4) M (10 nmol) and 10(-3) M (100 nmol) EKC/D (100 microl/rat). Similarly, injection of NK1R antagonists such as L-703,606 and Spantide I (10(-3) M) attenuated the increased paw volume following inflammation. Furtherm...Continue Reading

References

Sep 28, 1998·The European Journal of Neuroscience·H S Li, Z Q Zhao
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nigel M PagePhilip J Lowry
Jun 30, 2004·Cellular and Molecular Life Sciences : CMLS·N M Page
Nov 11, 2008·Biochemical and Biophysical Research Communications·Rumi NaonoToshikazu Nishimori
Oct 27, 2009·Peptides·Yinliang Yang, Shouliang Dong

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Citations

Mar 26, 2013·Journal of the Peripheral Nervous System : JPNS·Andressa Perin-MartinsLuana Fischer
Feb 26, 2013·British Journal of Clinical Pharmacology·Erika PintérJános Szolcsányi
Dec 3, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Luana FischerCarlos Amílcar Parada

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