Subcutaneous lispro and intravenous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients

International Journal of Clinical Practice
H O ErsözS S Karti

Abstract

In this prospective, randomised, open trial, we wanted to evaluate the efficacy and safety of hourly subcutaneous (SC) insulin lispro administration in the treatment of diabetic ketoacidosis (DKA) in comparison with intravenous (IV) regular insulin treatment. Twenty patients were enrolled in the study. The patients were randomly assigned into two groups. Following a bolus injection of 0.15 U/kg IV regular insulin, group L received half of this dose as hourly SC insulin lispro while group R was treated conventionally with IV regular insulin infusion. At the end of treatment period, time that needed for normalisation of serum glucose, beta-hydroxybutyrate, blood pH and urine ketone levels were not different in groups L and R. There was no mortality or serious side effects in both groups. In this study, we revealed that treatment of mild and moderate DKA with SC insulin lispro is equally effective and safe in comparison with IV regular insulin.

References

Aug 4, 1977·The New England Journal of Medicine·J N FisherA E Kitabchi
Oct 1, 1977·La Nouvelle presse médicale·J MirouzeJ L Selam
Oct 1, 1977·Archives of Internal Medicine·K G Alberti
Oct 1, 1976·The Journal of Pediatrics·M M Martin, A A Martin
May 5, 1973·Lancet·N G SolerJ M Malins
May 1, 1983·American Journal of Epidemiology·G A FaichS E Ellis
Nov 1, 1993·The American Journal of the Medical Sciences·M E MayJ King
Apr 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·A BasuA D Wright
Oct 25, 1996·The Medical Letter on Drugs and Therapeutics
Jul 17, 1997·The New England Journal of Medicine·F Holleman, J B Hoekstra
Jan 10, 2001·Endocrinology and Metabolism Clinics of North America·N H White
Dec 26, 2002·Journal of Critical Care·Amado X FreireAbbas E Kitabchi
Dec 28, 2002·Diabetes Care·Abbas E KitabchiUNKNOWN American Diabetes Association
Jul 28, 2004·Diabetes Care·Guillermo E UmpierrezAbbas E Kitabchi

❮ Previous
Next ❯

Citations

Feb 1, 2007·International Journal of Clinical Practice·S Roy ChowdhuryS E R S Stanaway
Mar 16, 2016·Metabolism: Clinical and Experimental·Ebenezer A Nyenwe, Abbas E Kitabchi
Apr 29, 2014·Emergency Medicine Clinics of North America·Brian CorwellGeorge C Willis
Feb 12, 2013·European Journal of Internal Medicine·Leonid BarskiAlan Jotkowitz
Jun 13, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Carly PetersonK Annette Mizuguchi
Feb 20, 2016·Nature Reviews. Endocrinology·Guillermo Umpierrez, Mary Korytkowski
Nov 28, 2006·Diabetes Research and Clinical Practice·Otto M HenriksenOle Lander Svendsen
Mar 24, 2016·Pediatric Diabetes·Michal CohenNaim Shehadeh
Oct 8, 2011·Diabetes Research and Clinical Practice·Ebenezer A Nyenwe, Abbas E Kitabchi
Apr 5, 2017·The Medical Clinics of North America·Maya FayfmanGuillermo E Umpierrez
Jul 1, 2017·Frontiers in Endocrinology·Tara T T TranElif I I Ekinci
Mar 8, 2017·World Journal of Diabetes·Yamely MendezJoseph Varon
Jan 23, 2016·The Cochrane Database of Systematic Reviews·Carlos A Andrade-CastellanosDaniel A Gonzalez-Padilla
Mar 8, 2018·Journal of Feline Medicine and Surgery·Eleonora MalerbaFederico Fracassi
Jul 2, 2008·Paediatric Drugs·Nicole A Sherry, Lynne L Levitsky
Jun 13, 2009·Journal of Korean Medical Science·Han-Young JungUNKNOWN Korean Academy of Medical Sciences Pediatric Impairment Evaluation Research Team
Jun 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Nadine E PalermoMarie E McDonnell
Jan 11, 2020·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·Karli EdholmStacy A Johnson
Mar 1, 2016·Expert Review of Endocrinology & Metabolism·Isabel AnzolaGuillermo E Umpierrez
Dec 14, 2018·Pharmacy : Journal of Pharmacy, Education and Practice·Hannah D BrownJohn H Patka
May 31, 2019·BMJ : British Medical Journal·Esra Karslioglu FrenchMary T Korytkowski
May 16, 2020·Nature Reviews. Disease Primers·Ketan K DhatariyaGuillermo E Umpierrez
Jul 11, 2020·Reviews on Recent Clinical Trials·Dario PitoccoAlfredo Pontecorvi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.