Abstract
We recently reported that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone. The purpose of this study was to test the hypothesis that left thoracic SCNA is more accurate than heart rate variability (HRV) in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction (MI). We used an implanted radiotransmitter to study left stellate ganglion nerve activity (SGNA), vagal nerve activity (VNA), and thoracic SCNA in 9 dogs at baseline and up to 8 weeks after MI. HRV was determined based on time-domain, frequency-domain, and nonlinear analyses. The correlation coefficients between integrated SGNA and SCNA averaged 0.74 (95% confidence interval [CI] 0.41-1.06) at baseline and 0.82 (95% CI, 0.63-1.01) after MI (P <.05 for both). The absolute values of the correlation coefficients were significantly larger than that between SGNA and HRV analysis based on time-domain, frequency-domain, and nonlinear analyses, respectively, at baseline (P <.05 for all) and after MI (P <.05 for all). There was a clear increment of SGNA and SCNA at 2, 4, 6, and 8 weeks after MI, whereas HRV parameters showed no significant changes. Significant circadian variations were noted in SCNA, SGNA, and all HRV paramet...Continue Reading
References
Mar 1, 1985·IEEE Transactions on Bio-medical Engineering·J Pan, W J Tompkins
Mar 29, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·C F Notarius, J S Floras
Jan 15, 2002·Journal of Anatomy·L RamsaroopK S Satyapal
Aug 11, 2004·Circulation·Prashanthan SandersJonathan M Kalman
May 12, 2005·Anatomy and Embryology·Tomokazu Kawashima
Jan 27, 2006·Annals of Neurology·Vincenzo DonadioLucio Santoro
May 23, 2006·Lancet·Axel BauerGeorg Schmidt
Nov 7, 2006·Journal of Neuroscience Methods·Robert J BrychtaAndré Diedrich
Apr 7, 2007·Chaos·Jan W KantelhardtGeorg Schmidt
Dec 26, 2008·European Heart Journal·Axel BauerGeorg Schmidt
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Gianfranco PiccirilloPeng-Sheng Chen
Mar 28, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Heikki V HuikuriGian Domenico Pinna
Sep 6, 2011·Experimental Physiology·David S GoldsteinYehonatan Sharabi
Nov 2, 2011·The Journal of Physiology·Yoshi-ichiro KamijoHiroshi Nose
Dec 7, 2011·Frontiers in Physiology·George E Billman
Mar 3, 2012·Journal of the American College of Cardiology·Seongwook HanLan S Chen
Jul 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Davide MartelliRohit Ramchandra
Aug 6, 2014·Journal of Cardiovascular Electrophysiology·Eric A RobinsonPeng-Sheng Chen
Dec 3, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Anisiia DoytchinovaPeng-Sheng Chen
Citations
Jan 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Govind Krishna Kumar NairKumaraswamy Nanthakumar
Oct 11, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Wei-Chung TsaiPeng-Sheng Chen
Apr 8, 2020·Frontiers in Physiology·Richard Ang, Nephtali Marina
Feb 28, 2019·JCI Insight·Takashi KusayamaPeng-Sheng Chen
Apr 22, 2020·Nature Protocols·Takashi KusayamaPeng-Sheng Chen
Dec 1, 2015·JACC. Clinical Electrophysiology·Sébastien P J KrulJoris R de Groot
Apr 2, 2021·PloS One·Hugo D CritchleyJamie Ward
Apr 13, 2021·Frontiers in Cardiovascular Medicine·Yuhong WangHong Jiang
May 26, 2018·JACC. Clinical Electrophysiology·Richard S SheltonThomas H Everett
Jul 20, 2021·Journal of cardiology·Mu ChenYi-Gang Li