Subcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Yi-Hsin ChanPeng-Sheng Chen

Abstract

We recently reported that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone. The purpose of this study was to test the hypothesis that left thoracic SCNA is more accurate than heart rate variability (HRV) in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction (MI). We used an implanted radiotransmitter to study left stellate ganglion nerve activity (SGNA), vagal nerve activity (VNA), and thoracic SCNA in 9 dogs at baseline and up to 8 weeks after MI. HRV was determined based on time-domain, frequency-domain, and nonlinear analyses. The correlation coefficients between integrated SGNA and SCNA averaged 0.74 (95% confidence interval [CI] 0.41-1.06) at baseline and 0.82 (95% CI, 0.63-1.01) after MI (P <.05 for both). The absolute values of the correlation coefficients were significantly larger than that between SGNA and HRV analysis based on time-domain, frequency-domain, and nonlinear analyses, respectively, at baseline (P <.05 for all) and after MI (P <.05 for all). There was a clear increment of SGNA and SCNA at 2, 4, 6, and 8 weeks after MI, whereas HRV parameters showed no significant changes. Significant circadian variations were noted in SCNA, SGNA, and all HRV paramet...Continue Reading

References

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Citations

Jan 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Govind Krishna Kumar NairKumaraswamy Nanthakumar
Oct 11, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Wei-Chung TsaiPeng-Sheng Chen
Apr 8, 2020·Frontiers in Physiology·Richard Ang, Nephtali Marina
Feb 28, 2019·JCI Insight·Takashi KusayamaPeng-Sheng Chen
Dec 1, 2015·JACC. Clinical Electrophysiology·Sébastien P J KrulJoris R de Groot

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